Gene: RGMA
Official Full Name: repulsive guidance molecule BMP co-receptor aprovided by HGNC
Gene Summary: This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14574 | RGMA Knockout cell line (HCT 116) | Human | RGMA | 1:2~1:4 | Negative | Online Inquiry |
KO14575 | RGMA Knockout cell line (HEK293) | Human | RGMA | 1:3~1:6 | Negative | Online Inquiry |
RGMA Gene Knockout Cell Lines represent a pioneering advancement in genetic research and experimental therapeutics. These specialized mammalian cell lines have been engineered to specifically disrupt the RGMA gene, which is known to play a pivotal role in neural development and regeneration, as well as in various pathological conditions. By utilizing CRISPR-Cas9 technology, the RGMA gene knockout facilitates precise modifications in the genomic sequence, allowing researchers to study the downstream effects of RGMA loss on cellular processes and signaling pathways.
The primary mechanism of RGMA Gene Knockout Cell Lines involves targeted gene editing, which leads to the complete ablation of RGMA protein expression. This disruption allows scientists to elucidate the gene's functional significance in biological processes such as synaptic plasticity, axonal growth, and immune responses. In research and clinical settings, these cell lines are invaluable tools for drug discovery and development, enabling the screening of potential therapeutic compounds that modulate the RGMA pathway, thus holding promise for conditions such as spinal cord injuries, neurodegenerative diseases, and cancer.
One of the major advantages of RGMA Gene Knockout Cell Lines is their specificity and reproducibility compared to competing genetic models. Traditional knockout strategies often result in off-target effects that can confound results, whereas our cell lines provide uncompromised assay conditions, ensuring that changes observed are a direct consequence of RGMA disruption. Additionally, these cell lines are readily available and easy to maintain, facilitating their integration into diverse research applications.
For researchers and clinicians seeking to deepen their understanding of RGMA functions or to explore novel therapeutic avenues, RGMA Gene Knockout Cell Lines are an essential asset. The insights gained through utilizing these models can significantly enhance the development of targeted treatments and innovative research strategies.
Our company is committed to delivering cutting-edge biological products that empower scientific discovery and clinical advancements. With expertise in genetic engineering and a focus on quality, we pride ourselves on offering tools that are not only scientifically robust but also strategically aligned with the needs of the research community.
Please note that all services are for research use only. Not intended for any clinical use.
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