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RGCC Knockout Cell Lines

Gene: RGCC

Official Full Name: regulator of cell cycleprovided by HGNC

Gene Summary: This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27252 RGCC Knockout cell line (HeLa) Human RGCC 1:3~1:6 Negative Online Inquiry
KO27253 RGCC Knockout cell line (HCT 116) Human RGCC 1:2~1:4 Negative Online Inquiry
KO27254 RGCC Knockout cell line (HEK293) Human RGCC 1:3~1:6 Negative Online Inquiry
KO27255 RGCC Knockout cell line (A549) Human RGCC 1:3~1:4 Negative Online Inquiry

Background

RGCC Gene Knockout Cell Lines are sophisticated biological tools designed to facilitate the in-depth analysis of gene function by eliminating the expression of specific target genes. Utilizing advanced CRISPR-Cas9 genome editing technology, these cell lines allow researchers to create precise gene knockouts, effectively enabling studies on the phenotypic consequences of gene disruption. By systematically disabling specific genes, scientists can uncover their roles in cellular processes, disease mechanisms, and therapeutic responses.

The primary function of RGCC Gene Knockout Cell Lines lies in their ability to provide models that mirror genetic mutations observed in various diseases, including cancer and genetic disorders. The CRISPR-Cas9 mechanism introduces double-strand breaks at targeted locations in the genome, which are typically repaired via non-homologous end joining, leading to gene disruption. This selective gene inactivation opens avenues for investigating gene pathways and interactions in both basic research and applied clinical settings.

Scientifically, these knockout cell lines are pivotal in drug discovery and development, allowing for the screening of new therapeutic compounds by identifying potential targets and assessing drug efficacy. Additionally, they play significant roles in systems biology, synthetic biology, and the exploration of gene-environment interactions.

Compared to conventional knockout methods, RGCC Gene Knockout Cell Lines offer higher specificity and efficiency, reducing off-target effects for more reliable results. They are also accompanied by comprehensive validation protocols ensuring the reproducibility of experimental outcomes.

For researchers and clinicians, the value of these cell lines is exemplified through their versatility and the robust data they generate, which can influence strategic decision-making in research and therapeutic interventions.

At [Your Company Name], we are dedicated to providing the highest quality biological products and resources, leveraging our expertise in genetic engineering to equip researchers with innovative tools that enhance their scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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