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RBPJ Knockout Cell Lines

Gene: RBPJ

Official Full Name: recombination signal binding protein for immunoglobulin kappa J regionprovided by HGNC

Gene Summary: The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11338 RBPJ Knockout cell line (HeLa) Human RBPJ 1:3~1:6 Negative Online Inquiry
KO11339 RBPJ Knockout cell line (HCT 116) Human RBPJ 1:2~1:4 Negative Online Inquiry
KO11340 RBPJ Knockout cell line (HEK293) Human RBPJ 1:3~1:6 Negative Online Inquiry
KO11341 RBPJ Knockout cell line (A549) Human RBPJ 1:3~1:4 Negative Online Inquiry

Background

RBPJ Gene Knockout Cell Lines are specialized human cell lines engineered to lack the RBPJ gene, which plays a crucial role in the Notch signaling pathway. This product offers a powerful tool for researchers aiming to investigate the molecular mechanisms by which Notch signaling influences cellular processes such as differentiation, proliferation, and apoptosis. By creating a knockout model, scientists can effectively analyze the functional consequences of RBPJ absence, thereby elucidating its contributions to various biological processes and disease states.

These cell lines operate by harboring a precise genetic modification that inhibits RBPJ gene expression, allowing for the detailed study of Notch pathway dynamics in a controlled environment. This unique mechanism provides invaluable insights into cellular responses under conditions of RBPJ deficiency, resulting in profound implications for understanding cancer biology, developmental biology, and regenerative medicine.

The scientific importance of RBPJ Gene Knockout Cell Lines extends into both research and clinical application, serving as compelling models for drug discovery, target validation, and biomarker development. Clinical researchers can utilize these lines to assess the therapeutic potential of novel compounds targeting the Notch pathway, ultimately contributing to improved patient outcomes.

Unlike other gene-editing tools or systems available on the market, our RBPJ knockout cell lines offer unmatched precision and reliability in the abrogation of RBPJ function. Complemented by comprehensive technical support and validation data, researchers can trust these lines for consistent results.

The value of RBPJ Gene Knockout Cell Lines cannot be overstated; they empower researchers and clinicians to delve deeper into critical biological processes and therapeutic avenues. At our company, we pride ourselves on our extensive experience and commitment to advancing research in cellular and molecular biology, offering products that meet the highest standards of quality and scientific rigor.

Please note that all services are for research use only. Not intended for any clinical use.

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