Gene: RBL1
Official Full Name: RB transcriptional corepressor like 1provided by HGNC
Gene Summary: The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11506 | RBL1 Knockout cell line (HeLa) | Human | RBL1 | 1:3~1:6 | Negative | Online Inquiry |
KO11507 | RBL1 Knockout cell line (HCT 116) | Human | RBL1 | 1:2~1:4 | Negative | Online Inquiry |
KO11508 | RBL1 Knockout cell line (HEK293) | Human | RBL1 | 1:3~1:6 | Negative | Online Inquiry |
KO11509 | RBL1 Knockout cell line (A549) | Human | RBL1 | 1:3~1:4 | Negative | Online Inquiry |
RBL1 Gene Knockout Cell Lines are a sophisticated and tailored biological tool designed for researchers aiming to elucidate the role of the RBL1 gene in various cellular processes. By employing advanced gene editing techniques such as CRISPR-Cas9, these cell lines feature the precise knockout of the RBL1 gene, enabling the study of its functions in cell cycle regulation, differentiation, and oncogenesis. The knockout mechanism disrupts the gene's coding sequence, leading to a loss of function that researchers can leverage to investigate the downstream effects on cellular pathways.
The scientific importance of RBL1 Gene Knockout Cell Lines lies in their application across multiple fields, including cancer research, molecular biology, and pharmacology. With RBL1 being associated with tumor suppression, these cell lines serve as a critical platform for studying the gene's role in tumorigenesis and for screening potential therapeutic targets. Researchers can assess phenotypic changes, analyze signaling pathways, and explore drug responses in a controlled experimental setting.
Compared to alternative models, RBL1 Gene Knockout Cell Lines offer several key advantages. They provide a consistent and reproducible system with a well-characterized genetic background, ensuring that variations in experimental outcomes are minimized. Additionally, these cell lines can be integrated into high-throughput screening assays, making them particularly valuable for large-scale studies or drug discovery efforts.
For researchers, clinicians, and biopharmaceutical companies, the intrinsic value of RBL1 Gene Knockout Cell Lines is evident. They enable deeper insights into gene function and are instrumental in advancing our understanding of complex diseases, ultimately contributing to the development of novel therapeutic strategies.
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