Gene: RARB
Official Full Name: retinoic acid receptor betaprovided by HGNC
Gene Summary: This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02266 | RARB Knockout cell line (HEK293) | Human | RARB | 1:3~1:6 | Negative | Online Inquiry |
KO02267 | RARB Knockout cell line (A549) | Human | RARB | 1:3~1:4 | Negative | Online Inquiry |
RARB Gene Knockout Cell Lines represent a groundbreaking tool in the field of molecular biology, specifically designed for the study of retinoic acid receptor beta (RARB) function and its downstream signaling pathways. These cell lines are genetically modified to lack the functional RARB gene, allowing researchers to investigate the physiological roles of RARB in various cellular contexts without the influence of the receptor’s activity.
The primary function of RARB Gene Knockout Cell Lines is to facilitate the dissection of RARB-mediated gene regulation and its contributions to processes such as cell differentiation, proliferation, and apoptosis. By employing these knockout models, scientists can elucidate the molecular mechanisms underlying RARB’s role in development and disease, including its implications in cancer biology and metabolic disorders. The absence of RARB enables more nuanced studies into the retinoid signaling pathway, enhancing our understanding of its biological significance.
In research and clinical applications, these knockout cell lines provide a robust platform for drug discovery and therapeutic interventions targeting RARB-related pathways. They serve as valuable models for testing the efficacy of retinoid compounds and identifying potential biomarkers for diseases associated with aberrant retinoic acid signaling.
One of the significant advantages of RARB Gene Knockout Cell Lines is their specificity and reliability in eliminating RARB function, offering a more accurate representation of its absence compared to traditional pharmacological approaches. This specificity allows for the generation of cleaner data, minimizing off-target effects commonly encountered with other gene modulation techniques. Additionally, the availability of these knockout lines accelerates experimental timelines, enabling rapid and reproducible results.
Researchers and clinicians will find RARB Gene Knockout Cell Lines invaluable for advancing their studies in genetic regulation and therapeutic development. By seamlessly integrating into ongoing projects, these lines streamline the exploration of retinoid biology and impact fundamental insights into gene function.
With a commitment to advancing research tools, our company leverages expertise in genetic engineering and cell line development to deliver high-quality biological products. Our RARB Gene Knockout Cell Lines epitomize our dedication to providing reliable resources that empower the scientific community to drive discovery and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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