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RARA Knockout Cell Lines

Gene: RARA

Official Full Name: retinoic acid receptor alphaprovided by HGNC

Gene Summary: This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02255 RARA Knockout cell line (HeLa) Human RARA 1:3~1:6 Negative Online Inquiry
KO02256 RARA Knockout cell line (HCT 116) Human RARA 1:2~1:4 Negative Online Inquiry
KO02257 RARA Knockout cell line (HEK293) Human RARA 1:3~1:6 Negative Online Inquiry
KO02258 RARA Knockout cell line (A549) Human RARA 1:3~1:4 Negative Online Inquiry

Background

RARA Gene Knockout Cell Lines are specifically engineered cellular models that have had the Retinoic Acid Receptor Alpha (RARA) gene precisely disrupted through advanced genetic editing techniques. RARA is instrumental in regulating a multitude of biological processes, including cell differentiation, proliferation, and apoptosis, particularly in hematopoietic and neural tissues. By effectively knocking out the RARA gene, these cell lines allow researchers to investigate the receptor's role in various pathophysiological contexts, including cancer, autoimmune diseases, and developmental disorders.

The key function of RARA Gene Knockout Cell Lines lies in their unique ability to facilitate the dissection of signaling pathways where RARA is involved. When RARA is absent, researchers can observe phenotypic changes and analyze compensatory mechanisms within the cell, providing critical insights into the molecular underpinnings of diseases. These knockout models serve as powerful tools in drug discovery, particularly for identifying compounds that modulate RARA signaling, which is essential for devising targeted therapeutic strategies.

The scientific importance of RARA Gene Knockout Cell Lines is underscored by their utility in both basic and applied research settings. They enable the investigation of RARA's interactions in the Retinoic Acid signaling pathway and its impact on gene expression profiles, resulting in the generation of high-quality data that can drive forward scientific understanding and innovation in clinical research.

What sets RARA Gene Knockout Cell Lines apart from alternatives is their validated, consistent knockout efficiency and the extensive background data supporting their use. Each cell line undergoes rigorous characterization to ensure reproducibility, which is vital for researchers conducting studies where accuracy is paramount. These models can be conveniently utilized across various platforms for high-throughput screening, enabling the identification of potential therapeutic agents more efficiently.

Investing in RARA Gene Knockout Cell Lines can significantly contribute to advancing research and clinical applications, particularly for those focused on understanding the complexities of gene regulation and signaling pathways. By choosing our product, researchers gain access to a premier resource designed with precision and quality assurance in mind, backed by our company's extensive expertise in gene editing technologies and commitment to supporting innovative biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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