Gene: RAP1GAP
Official Full Name: RAP1 GTPase activating proteinprovided by HGNC
Gene Summary: This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08740 | RAP1GAP Knockout cell line (HeLa) | Human | RAP1GAP | 1:3~1:6 | Negative | Online Inquiry |
KO08741 | RAP1GAP Knockout cell line (HCT 116) | Human | RAP1GAP | 1:2~1:4 | Negative | Online Inquiry |
KO08742 | RAP1GAP Knockout cell line (HEK293) | Human | RAP1GAP | 1:3~1:6 | Negative | Online Inquiry |
KO08743 | RAP1GAP Knockout cell line (A549) | Human | RAP1GAP | 1:3~1:4 | Negative | Online Inquiry |
RAP1GAP Gene Knockout Cell Lines are genetically engineered cell models designed to specifically knock out the RAP1GAP gene, which encodes a GTPase-activating protein that plays a crucial role in the regulation of RAS signaling pathways. By disrupting the function of RAP1GAP, these cell lines serve as pivotal tools for elucidating the molecular mechanisms of cellular signaling, particularly relating to cell proliferation, differentiation, and apoptosis.
These cell lines utilize advanced CRISPR/Cas9 technology to achieve precise gene knockout, ensuring high specificity and efficiency. Through the loss of RAP1GAP, researchers can investigate the downstream effects on RAS activity and associated pathways, providing essential insights into various biological processes and disease states, including cancer. This gene’s role in oncogenic signaling underscores its potential as a therapeutic target, making these knockout cell lines valuable for high-throughput screening of potential drug candidates and understanding resistance mechanisms.
One of the key advantages of RAP1GAP Gene Knockout Cell Lines is their reproducibility and reliability in delivering consistent results, which are crucial in experimental research. Compared to alternative models, these cell lines allow for real-time monitoring of cellular responses, thereby providing a unique perspective on the dynamic interactions within signaling pathways. Additionally, their versatility in assay development makes them suitable for both small-scale studies and larger applications in clinical translational research.
The value proposition of these cell lines is clear: they empower researchers and clinicians to delve deeper into the complexities of cell signaling and therapeutic interventions. Moreover, the expertise and commitment to quality from our company ensures that these models are derived and validated under stringent conditions, providing exceptional reliability for your research initiatives. Whether you are investigating fundamental biology or pioneering new clinical therapies, RAP1GAP Gene Knockout Cell Lines represent an indispensable resource in the modern biomedical research toolkit.
Please note that all services are for research use only. Not intended for any clinical use.
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