Gene: RAB7A
Official Full Name: RAB7A, member RAS oncogene familyprovided by HGNC
Gene Summary: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04179 | RAB7A Knockout cell line (HeLa) | Human | RAB7A | 1:3~1:6 | Negative | Online Inquiry |
KO04180 | RAB7A Knockout cell line (HCT 116) | Human | RAB7A | 1:2~1:4 | Negative | Online Inquiry |
KO04181 | RAB7A Knockout cell line (HEK293) | Human | RAB7A | 1:3~1:6 | Negative | Online Inquiry |
KO04182 | RAB7A Knockout cell line (A549) | Human | RAB7A | 1:3~1:4 | Negative | Online Inquiry |
RAB7A Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to enable the study of RAB7A, a critical member of the RAB GTPase family involved in the regulation of intracellular vesicle trafficking and organelle dynamics. These knockout cell lines have undergone targeted gene disruption to eliminate the expression of the RAB7A gene, facilitating researchers in investigating the specific biological roles of RAB7A in processes such as autophagy, endocytosis, and lysosomal function.
The key function of these cell lines lies in their ability to provide insights into the molecular pathways affected by the absence of RAB7A. By comparing these knockout cells with their wild-type counterparts, researchers can elucidate the mechanisms by which RAB7A influences vesicular transport, cellular homeostasis, and potential implications in disease states such as neurodegeneration and cancer. Through loss-of-function studies, scientists can also explore the impact of RAB7A on cellular signaling pathways and its interactions with other proteins, enhancing our understanding of fundamental cell biology.
The scientific importance of RAB7A gene knockout cell lines is underscored by their applications in both research and clinical settings. They serve as invaluable tools in drug discovery and development, particularly for compounds targeting RAB7A-related pathways, which can shed light on novel therapeutic approaches for treating diseases associated with lysosomal dysfunction.
What sets these knockout cell lines apart from alternatives is their precise engineering, which ensures consistent and reproducible results. Additionally, our RAB7A Gene Knockout Cell Lines are validated for a wide range of assays, including immunofluorescence, Western blotting, and flow cytometry, providing researchers with a reliable platform for experimental design.
For researchers and clinicians striving to deepen their understanding of intracellular transport mechanisms and related pathologies, these knockout cell lines represent a powerful resource. Our company prides itself on delivering high-quality biological products backed by cutting-edge research and development, ensuring that our clients have access to reliable and innovative tools essential for advancing their scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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