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RAB6A Knockout Cell Lines

Gene: RAB6A

Official Full Name: RAB6A, member RAS oncogene familyprovided by HGNC

Gene Summary: This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04430 RAB6A Knockout cell line (HeLa) Human RAB6A 1:3~1:6 Negative Online Inquiry
KO04431 RAB6A Knockout cell line (HCT 116) Human RAB6A 1:2~1:4 Negative Online Inquiry
KO04432 RAB6A Knockout cell line (HEK293) Human RAB6A 1:3~1:6 Negative Online Inquiry
KO04433 RAB6A Knockout cell line (A549) Human RAB6A 1:3~1:4 Negative Online Inquiry

Background

RAB6A Gene Knockout Cell Lines are genetically modified cell lines specifically designed to study the functions and biological pathways associated with the RAB6A gene. RAB6A encodes a member of the RAS oncogene family, which plays a crucial role in intracellular transport processes, particularly in the Golgi apparatus. By effectively knocking out the RAB6A gene, researchers can elucidate its role in membrane trafficking, signal transduction, and cellular processes such as proliferation and differentiation.

The mechanism of action involves targeted gene editing technologies such as CRISPR-Cas9, which results in the complete disruption of the RAB6A gene, consequently allowing scientists to observe the resultant phenotypic changes. Researchers utilize these cell lines to investigate the implications of RAB6A in disease models, including cancer and neurodegenerative disorders, providing insights into potential therapeutic targets.

The scientific importance of RAB6A Gene Knockout Cell Lines extends to both basic research and clinical applications. In research settings, these cell lines enable the dissection of complex biological pathways and offer a platform for drug development aimed at modulating RAB6A's activity. In clinical settings, understanding the implications of RAB6A mutations can lead to the identification of biomarkers for disease prognosis and treatment responses.

Compared to traditional models, our RAB6A Gene Knockout Cell Lines provide a more precise tool for studying gene function due to their specificity and the reproducibility of phenotypic outcomes. They eliminate the confounding effects of endogenous RAB6A expression, setting a superior benchmark for experimental rigor.

Valuable to researchers and clinicians alike, these cell lines empower the exploration of novel therapeutic avenues and foster a deeper understanding of disease mechanisms. Our company, adept in advanced genetic engineering techniques and committed to quality, offers the expertise and support necessary to facilitate ground-breaking discoveries in the field of cell biology and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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