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RAB34 Knockout Cell Lines

Gene: RAB34

Official Full Name: RAB34, member RAS oncogene familyprovided by HGNC

Gene Summary: This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. An alternatively spliced transcript variant produces the nine-amino acid residue-repeats (NARR) protein, which is a functionally distinct nucleolar protein resulting from a different reading frame. [provided by RefSeq, Dec 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25344 RAB34 Knockout cell line (HeLa) Human RAB34 1:3~1:6 Negative Online Inquiry
KO25345 RAB34 Knockout cell line (HCT 116) Human RAB34 1:2~1:4 Negative Online Inquiry
KO25346 RAB34 Knockout cell line (HEK293) Human RAB34 1:3~1:6 Negative Online Inquiry
KO25347 RAB34 Knockout cell line (A549) Human RAB34 1:3~1:4 Negative Online Inquiry

Background

RAB34 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to elucidate the functional roles of the RAB34 gene, a member of the RAB family of small GTPases known for their involvement in vesicular trafficking and cellular compartmentalization. These knockout cell lines exhibit a complete absence of the RAB34 protein, providing an invaluable tool for researchers investigating the gene's contribution to various biological processes and disease states.

The fundamental mechanism of RAB34 involves its regulation of endosomal fusion and the trafficking of proteins to lysosomes, impacting processes such as autophagy and immune response. By utilizing RAB34 knockout cell lines, scientists can meticulously analyze the downstream effects of its depletion, offering insights into the intricate signaling pathways and cellular interactions that underline numerous pathological conditions, including cancer and neurodegenerative diseases.

The scientific importance of utilizing RAB34 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. These cell lines serve as platforms for drug discovery, allowing researchers to identify potential therapeutic targets and evaluate the efficacy of novel compounds. Additionally, they can aid in the development of gene therapies by providing a clearer understanding of gene function in a controlled environment.

What sets these knockout cell lines apart from alternative models is their precision and specificity. While traditional knockdown techniques may result in residual protein expression, leading to ambiguous results, our RAB34 knockout cell lines provide unequivocal loss of gene function, ensuring experimental reliability. Moreover, they are derived from robust and widely utilized laboratory conditions, guaranteeing compatibility with standard assays and protocols, a feature that enhances their utility across various applications.

For researchers and clinicians seeking to unravel the complexities of cellular behaviors, RAB34 Gene Knockout Cell Lines are not just valuable tools; they are essential for advancing our understanding of cellular mechanisms that drive health and disease. Our commitment to cutting-edge genetic engineering and rigorous quality control underscores our expertise in providing reliable biological products. By choosing our offerings, users benefit from our extensive experience in the field, ensuring access to innovative solutions that align with their research and clinical goals.

Please note that all services are for research use only. Not intended for any clinical use.

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