Gene: QDPR
Official Full Name: quinoid dihydropteridine reductaseprovided by HGNC
Gene Summary: This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35737 | QDPR Knockout cell line (HeLa) | Human | QDPR | 1:3~1:6 | Negative | Online Inquiry |
KO35738 | QDPR Knockout cell line (HCT 116) | Human | QDPR | 1:2~1:4 | Negative | Online Inquiry |
KO35739 | QDPR Knockout cell line (HEK293) | Human | QDPR | 1:3~1:6 | Negative | Online Inquiry |
KO35740 | QDPR Knockout cell line (A549) | Human | QDPR | 1:3~1:4 | Negative | Online Inquiry |
QDPR Gene Knockout Cell Lines are a revolutionary tool designed for advanced molecular and cellular research, specifically targeting the dysfunction of the Quinoid Dihydropteridine Reductase (QDPR) gene. These knockout cell lines are engineered to lack functional QDPR, allowing researchers to study the gene's role in various biological processes.
The key mechanism of action involves the targeted deletion of the QDPR gene using CRISPR-Cas9 technology, creating a model that effectively mimics the pathological features associated with QDPR deficiency. By providing a platform to investigate the impact of QDPR-related disorders, such as hyperphenylalaninemia, these cell lines enable in-depth analyses of metabolic pathways and their implications in neurological deficits and cognitive impairment.
The scientific importance of QDPR Gene Knockout Cell Lines extends significantly into both basic research and clinical applications. They facilitate the investigation of gene function, the exploration of potential therapeutic targets, and the development of enzyme replacement or gene therapies. In research settings, these cell lines can aid in high-throughput screening of pharmacological agents, providing insights into potential treatments for QDPR-related conditions.
One of the major advantages of our QDPR Gene Knockout Cell Lines is their high degree of specificity and reproducibility, unmatched by conventional knockout methods. Unlike alternative models that may possess residual gene expression or compensatory pathways, our lines offer a clean genetic background, ensuring more accurate experimental outcomes. This fidelity enhances the reliability of research findings and accelerates the drug discovery process.
For researchers and clinicians, the value of QDPR Gene Knockout Cell Lines lies in their capacity to bridge the gap between genotype and phenotype, offering a direct window into the molecular underpinnings of disease. The availability of these specialized cell lines presents a crucial advancement for those working to develop targeted therapies or studying metabolic disorders.
Our company is dedicated to providing high-quality, innovative biological products that support cutting-edge research and clinical advancements. With a strong foundation in genetic engineering and extensive expertise in cellular biology, we are committed to enriching the scientific community with tools that drive discovery and enhance patient care.
Please note that all services are for research use only. Not intended for any clinical use.
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