Gene: PUS1
Official Full Name: pseudouridine synthase 1provided by HGNC
Gene Summary: This gene encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. The encoded enzyme may play an essential role in tRNA function and in stabilizing the secondary and tertiary structure of many RNAs. A mutation in this gene has been linked to mitochondrial myopathy and sideroblastic anemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01366 | PUS1 Knockout cell line (HeLa) | Human | PUS1 | 1:3~1:6 | Negative | Online Inquiry |
KO07242 | PUS1 Knockout cell line (HCT 116) | Human | PUS1 | 1:2~1:4 | Negative | Online Inquiry |
KO07243 | PUS1 Knockout cell line (HEK293) | Human | PUS1 | 1:3~1:6 | Negative | Online Inquiry |
KO07244 | PUS1 Knockout cell line (A549) | Human | PUS1 | 1:3~1:4 | Negative | Online Inquiry |
PUS1 Gene Knockout Cell Lines are genetically engineered cell models specifically designed to study the role of the PUS1 gene in various biological processes. PUS1 encodes a protein involved in tRNA modification, crucial for proper protein synthesis and cellular function. By selectively disrupting the PUS1 gene in these cell lines, researchers can effectively analyze the downstream effects on gene expression, cellular metabolism, and overall phenotype, providing valuable insights into the gene's contributions to cellular homeostasis and disease mechanisms.
These cell lines operate through a mechanism of targeted gene disruption, often utilizing CRISPR/Cas9 technology, allowing for high efficiency and specificity in knocking out the PUS1 gene. The resultant phenotypic alterations can be systematically studied to elucidate PUS1's functions, making these cell lines indispensable tools in both fundamental research and applied biomedical studies.
The scientific importance of PUS1 Gene Knockout Cell Lines is evident in their potential applications across various fields, including cancer research, neurobiology, and developmental biology. By examining the impact of PUS1 loss on cellular processes, researchers can better understand disease pathways and identify novel therapeutic targets.
Compared to conventional gene knockout models, our PUS1 Gene Knockout Cell Lines offer enhanced reliability and consistency, as they are meticulously validated for specificity and functionality. Researchers benefit from these ready-to-use models, which streamline experimental workflows while reducing the time and resources spent on developing new knockout lines.
The value of PUS1 Gene Knockout Cell Lines cannot be overstated. They empower scientists and clinicians to investigate the intricacies of gene function and its implications in human health and disease. By leveraging these advanced models, researchers can accelerate discoveries that may lead to new diagnostics or therapeutic interventions.
At [Your Company Name], we specialize in developing high-quality biological products that support groundbreaking research. Our commitment to excellence in genetic engineering and cell line development ensures that your studies are built on a foundation of reliability and scientific rigor.
Please note that all services are for research use only. Not intended for any clinical use.
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