Gene: PTPRN2
Official Full Name: protein tyrosine phosphatase receptor type N2provided by HGNC
Gene Summary: This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35786 | PTPRN2 Knockout cell line (HCT 116) | Human | PTPRN2 | 1:2~1:4 | Negative | Online Inquiry |
KO35787 | PTPRN2 Knockout cell line (HEK293) | Human | PTPRN2 | 1:3~1:6 | Negative | Online Inquiry |
PTPRN2 Gene Knockout Cell Lines are specifically engineered cellular models that feature targeted disruptions in the PTPRN2 gene, which encodes the protein phosphatase receptor type N2. These cell lines are established using advanced CRISPR/Cas9 gene-editing technology, allowing for precise deletions or modifications within the gene's sequence. By knocking out PTPRN2, researchers can investigate the biological functions and implications of this gene, particularly in relation to its role in neuronal processes and potential associations with neurodegenerative diseases.
The key function of PTPRN2 lies in its involvement in cellular signaling pathways, particularly those that affect cell proliferation, survival, and differentiation. The knockout of this gene produces a cellular model that mimics the physiological impact arising from the loss of PTPRN2 activity, thus facilitating studies on its role in normal cellular functions and in the pathology of diseases such as diabetes and various cancers.
Scientifically, these cell lines are vital for research aimed at understanding the mechanisms underlying PTPRN2-related pathologies, providing insights into new therapeutic targets. Their utility extends to drug discovery, molecular pathology studies, and the validation of gene-targeting therapies. Compared to other models such as wild-type cell lines or traditional knockout mice, PTPRN2 Gene Knockout Cell Lines offer a more controlled and accessible system for evaluating gene function and drug interactions in vitro.
One compelling advantage of using PTPRN2 Gene Knockout Cell Lines is their potential for high-throughput screening, enabling researchers to efficiently evaluate large libraries of compounds and their effects on PTPRN2-related pathways. This translates to faster development cycles and quicker results in both academic and clinical research settings.
At [Your Company's Name], we have a strong commitment to advancing biological research through our innovative product offerings. Our expertise in gene editing and cell line development ensures that we provide high-quality, reproducible models that meet the needs of researchers and clinicians seeking to explore the frontiers of biomedical science.
Please note that all services are for research use only. Not intended for any clinical use.
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