Gene: PTPN3
Official Full Name: protein tyrosine phosphatase non-receptor type 3provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35825 | PTPN3 Knockout cell line (HeLa) | Human | PTPN3 | 1:3~1:6 | Negative | Online Inquiry |
KO35826 | PTPN3 Knockout cell line (HCT 116) | Human | PTPN3 | 1:2~1:4 | Negative | Online Inquiry |
KO35827 | PTPN3 Knockout cell line (HEK293) | Human | PTPN3 | 1:3~1:6 | Negative | Online Inquiry |
KO35828 | PTPN3 Knockout cell line (A549) | Human | PTPN3 | 1:3~1:4 | Negative | Online Inquiry |
PTPN3 Gene Knockout Cell Lines are engineered cell lines specifically designed to lack the protein tyrosine phosphatase non-receptor type 3 (PTPN3), a critical regulator of various cellular signaling pathways. By employing advanced CRISPR-Cas9 gene editing techniques, these cell lines provide researchers with valuable tools to investigate the precise roles of PTPN3 in cellular functions such as growth, differentiation, and response to external stimuli.
The mechanism behind the functionality of PTPN3 knockout cell lines lies in their ability to elicit alterations in signaling cascades that are normally modulated by PTPN3. By inhibiting the dephosphorylation of tyrosine residues on target proteins, PTPN3 knockout lines allow for enhanced or disrupted signaling responses, revealing insights into cellular processes like proliferation and apoptosis. This makes them indispensable in the study of cancer biology, autoimmune diseases, and metabolic disorders, where dysregulation of protein tyrosine phosphorylation plays a critical role.
In research and clinical settings, understanding PTPN3's function can significantly contribute to the development of novel therapeutic strategies. The ability to manipulate PTPN3 pathways in vitro opens avenues for drug discovery and the exploration of synergistic effects with existing therapies. Compared to traditional knockout methods, the precise nature of CRISPR technology ensures minimal off-target effects, enhancing experimental reliability.
Utilizing PTPN3 Gene Knockout Cell Lines empowers researchers and clinicians by providing a robust platform for elucidating molecular mechanisms underlying various pathologies. This product stands out for its specificity, ease of use, and the high-quality results it produces, making it a critical asset for advancing biomedical research.
Our company, with extensive expertise in genetic engineering and cell line development, is dedicated to providing innovative and reliable biological products that meet the rigorous standards of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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