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PTPN2 Knockout Cell Lines

Gene: PTPN2

Official Full Name: protein tyrosine phosphatase non-receptor type 2provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11193 PTPN2 Knockout cell line (HeLa) Human PTPN2 1:3~1:6 Negative Online Inquiry
KO11194 PTPN2 Knockout cell line (HCT 116) Human PTPN2 1:2~1:4 Negative Online Inquiry
KO11195 PTPN2 Knockout cell line (HEK293) Human PTPN2 1:3~1:6 Negative Online Inquiry
KO11196 PTPN2 Knockout cell line (A549) Human PTPN2 1:3~1:4 Negative Online Inquiry

Background

PTPN2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the protein tyrosine phosphatase non-receptor type 2 (PTPN2). This pivotal gene plays a crucial role in various cellular signaling pathways, particularly those influencing immune response and inflammation. By creating knockout cell lines, researchers can precisely investigate the biological function of PTPN2, determining its contributions to cellular processes such as cell differentiation, proliferation, and apoptosis.

The fundamental mechanism underlying these knockout cell lines involves CRISPR/Cas9 technology, which allows for precise genome editing. This method facilitates the targeted disruption of the PTPN2 gene, ensuring that the resulting cell lines provide a reliable model for studying the consequences of PTPN2 deficiency. Researchers can utilize these cells to explore how the absence of PTPN2 influences signaling pathways associated with autoimmune diseases, cancer, and metabolic disorders, thus opening new avenues for therapeutic intervention.

The scientific importance of PTPN2 Gene Knockout Cell Lines is underscored by their application in both basic and translational research. In clinical settings, these models enable the identification of novel drug targets and biomarkers, enhancing the development of personalized medicine strategies. Compared to conventional cell lines, these knockout models provide more accurate representations of disease states, leading to improved experimental outcomes.

What sets PTPN2 Gene Knockout Cell Lines apart from alternative models is their high specificity for the PTPN2 gene, coupled with the rigor of our validation processes that ensure reproducibility and reliability. Users benefit from well-characterized cell lines that can save time and resources while maximizing the relevance of their findings.

For researchers and clinicians aiming to elucidate the complexities of immune regulation and related pathologies, PTPN2 Gene Knockout Cell Lines represent a critical tool. Our commitment to high-quality biological products, backed by extensive expertise in genetic engineering, makes us a reliable partner in advancing your research goals with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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