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PTPN18 Knockout Cell Lines

Gene: PTPN18

Official Full Name: protein tyrosine phosphatase non-receptor type 18provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06860 PTPN18 Knockout cell line (HeLa) Human PTPN18 1:3~1:6 Negative Online Inquiry
KO06861 PTPN18 Knockout cell line (HCT 116) Human PTPN18 1:2~1:4 Negative Online Inquiry
KO06862 PTPN18 Knockout cell line (HEK293) Human PTPN18 1:3~1:6 Negative Online Inquiry
KO06863 PTPN18 Knockout cell line (A549) Human PTPN18 1:3~1:4 Negative Online Inquiry

Background

PTPN18 Gene Knockout Cell Lines are genetically-engineered cellular models designed to specifically disrupt the PTPN18 gene, which encodes a protein tyrosine phosphatase involved in regulating various signaling pathways associated with cell proliferation, differentiation, and immune response. By creating knockout models, researchers can probe the functional consequences of gene loss on cellular behavior and elucidate the role of PTPN18 in both normal physiological processes and disease states.

These cell lines work through the introduction of targeted gene modification techniques, such as CRISPR-Cas9 or homologous recombination, leading to a complete disruption of the PTPN18 gene. The resulting knockout cells provide a valuable tool for studying the downstream effects of PTPN18 absence, especially in the context of cancer biology, autoimmune diseases, and signaling pathway regulation. Researchers can conduct high-throughput screening, drug response assays, and mechanistic studies that provide insights into therapeutic targets and disease mechanisms.

The scientific importance of PTPN18 Gene Knockout Cell Lines lies in their applicability in both research and clinical settings. They offer an efficient model for understanding the pathophysiology of diseases linked to PTPN18 dysregulation, which could pave the way for novel therapeutic strategies. Moreover, these cell lines facilitate the development of biomarker discovery and individualized treatment approaches.

One of the key advantages of our PTPN18 Gene Knockout Cell Lines over traditional models is their precision and efficiency. Our cell lines are meticulously validated for consistent performance and reproducibility, thus providing researchers with highly reliable data. This specificity reduces the risk of off-target effects and enhances the accuracy of experimental outcomes. Furthermore, our product is backed by a robust support system, including protocols, troubleshooting assistance, and direct access to expert scientific knowledge.

Investing in PTPN18 Gene Knockout Cell Lines allows researchers and clinicians to delve deeper into the complexities of cellular signaling and disease, making this product invaluable for advancing biological research and therapeutic development. Our company is dedicated to providing high-quality biological products backed by extensive expertise in genetic engineering and cell line development, ensuring you have the tools necessary for your breakthrough discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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