Gene: PTPA
Official Full Name: protein phosphatase 2 phosphatase activatorprovided by HGNC
Gene Summary: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02218 | PTPA Knockout cell line (HeLa) | Human | PTPA | 1:3~1:6 | Negative | Online Inquiry |
KO02219 | PTPA Knockout cell line (HCT 116) | Human | PTPA | 1:2~1:4 | Negative | Online Inquiry |
KO02220 | PTPA Knockout cell line (HEK293) | Human | PTPA | 1:3~1:6 | Negative | Online Inquiry |
KO02221 | PTPA Knockout cell line (A549) | Human | PTPA | 1:3~1:4 | Negative | Online Inquiry |
PTPA Gene Knockout Cell Lines are specialized cellular models designed to facilitate the investigation of specific gene functions and their roles in various biological processes. These cell lines are created through advanced genetic engineering techniques, wherein the PTPA gene has been systematically disrupted, allowing researchers to study the effects of silencing this gene on cellular behavior and function. By leveraging a knockout approach, scientists can obtain insights into the pathological mechanisms underlying specific diseases or identify potential therapeutic targets.
The key mechanism by which PTPA Gene Knockout Cell Lines operate involves the absence of the PTPA gene, which impacts several critical cellular pathways associated with cell growth, differentiation, and apoptosis. This genetic alteration allows researchers to dissect the biological roles of PTPA and its involvement in signaling cascades, metabolic pathways, or cellular responses to stressors, making these cell lines invaluable in both basic and applied research contexts.
Scientifically, these knockout cell lines hold significant importance in the realms of cancer research, drug development, and genomic studies. They enable precise modeling of disease states and provide a robust platform for testing hypotheses regarding gene function and interactions in vitro. This makes them particularly relevant for translational research, where the understanding of gene roles can lead to innovative therapeutic strategies.
One of the primary advantages of PTPA Gene Knockout Cell Lines compared to alternative methodologies, such as RNA interference (RNAi) or chemical inhibition, is their permanence; the knockout phenotype is stable over multiple passages, thereby ensuring reliable and reproducible results across experiments. Furthermore, these cell lines afford researchers the opportunity to study long-term effects and cellular adaptations in response to genetic disruptions, which transient methods may not effectively capture.
Researchers and clinicians will find immense value in the PTPA Gene Knockout Cell Lines, as they provide a powerful tool for elucidating gene function and contribute to advancing therapeutic developments. By enabling critical insights into gene action, these cell lines serve as a foundation for groundbreaking research and clinical applications.
Our company prides itself on expertise in the development and characterization of innovative biological products, ensuring that our offerings, such as the PTPA Gene Knockout Cell Lines, meet the highest standards of quality and utility for the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.