Gene: PTDSS1
Official Full Name: phosphatidylserine synthase 1provided by HGNC
Gene Summary: The protein encoded by this gene catalyzes the formation of phosphatidylserine from either phosphatidylcholine or phosphatidylethanolamine. Phosphatidylserine localizes to the mitochondria-associated membrane of the endoplasmic reticulum, where it serves a structural role as well as a signaling role. Defects in this gene are a cause of Lenz-Majewski hyperostotic dwarfism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00520 | PTDSS1 Knockout cell line (HeLa) | Human | PTDSS1 | 1:3~1:6 | Negative | Online Inquiry |
KO07043 | PTDSS1 Knockout cell line (HCT 116) | Human | PTDSS1 | 1:2~1:4 | Negative | Online Inquiry |
KO07044 | PTDSS1 Knockout cell line (HEK293) | Human | PTDSS1 | 1:3~1:6 | Negative | Online Inquiry |
KO07045 | PTDSS1 Knockout cell line (A549) | Human | PTDSS1 | 1:3~1:4 | Negative | Online Inquiry |
PTDSS1 Gene Knockout Cell Lines are specialized cellular models created through genetic engineering to disrupt the expression of the phosphatidylserine synthase 1 (PTDSS1) gene. This gene is critical in phospholipid biosynthesis, specifically in the generation of phosphatidylserine, an essential component of cellular membranes involved in cell signaling and apoptosis. The PTDSS1 knockout cell lines serve as a valuable tool for researchers aiming to elucidate the role of PTDSS1 in various biological processes, including metabolic regulation and neurobiology.
The primary function of these knockout cell lines is to provide a controlled environment for investigating the consequences of PTDSS1 gene loss. By silencing this gene, researchers can study the impact on phosphatidylserine levels, membrane integrity, and cellular responses under stress conditions. This allows for in-depth analyses of cellular mechanisms related to diseases such as cancer, neurodegenerative disorders, and other conditions associated with altered membrane lipid composition.
Scientifically, PTDSS1 Gene Knockout Cell Lines hold immense potential in both research and clinical applications. They enable a platform for drug screening and therapeutic development, offering insights into new treatments targeting lipid metabolism and related diseases. Additionally, understanding the PTDSS1 function could provide pathways for biomarker discovery, contributing to advancements in precision medicine.
What sets these cell lines apart from alternative models is their specificity and functional fidelity. While other models may simulate gene silencing, PTDSS1 Gene Knockout Cell Lines offer a complete eradication of gene expression, enabling more accurate results. Furthermore, they are generated using robust techniques, ensuring high reproducibility and reliability in experimental outcomes.
For researchers and clinicians, the acquisition of PTDSS1 Gene Knockout Cell Lines represents an opportunity to explore novel hypotheses and validate current theories with a high degree of confidence. Their use can facilitate significant contributions to the fields of cellular biology and therapeutic research, maximizing productivity and innovation.
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Please note that all services are for research use only. Not intended for any clinical use.
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