Gene: PSMD9
Official Full Name: proteasome 26S subunit, non-ATPase 9provided by HGNC
Gene Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35843 | PSMD9 Knockout cell line (HeLa) | Human | PSMD9 | 1:3~1:6 | Negative | Online Inquiry |
KO35844 | PSMD9 Knockout cell line (HCT 116) | Human | PSMD9 | 1:2~1:4 | Negative | Online Inquiry |
KO35845 | PSMD9 Knockout cell line (HEK293) | Human | PSMD9 | 1:3~1:6 | Negative | Online Inquiry |
KO35846 | PSMD9 Knockout cell line (A549) | Human | PSMD9 | 1:3~1:4 | Negative | Online Inquiry |
PSMD9 Gene Knockout Cell Lines represent a pivotal innovation in the study of cellular processes and disease mechanisms. These cell lines are engineered to specifically disrupt the expression of the PSMD9 gene, which encodes a component of the 26S proteasome, a crucial multimolecular protease complex responsible for protein degradation and regulation of key cellular pathways. By knocking out the PSMD9 gene, researchers can investigate its role in various biological contexts, particularly in apoptosis, cell cycle regulation, and stress responses, providing insight into its contributions to disease states.
The primary function of these knockout cell lines lies in their ability to facilitate the study of PSMD9's regulatory role in protein homeostasis and its impact on important signal transduction pathways. Researchers can utilize these models to examine how the loss of PSMD9 influences cellular responses to stressors and its potential implications in oncogenesis, neurodegeneration, and other diseases where proteasome activity is disrupted.
Scientifically, PSMD9 Gene Knockout Cell Lines are invaluable in both research and clinical settings as they offer a controlled environment to dissect the molecular mechanisms underlying various pathologies. Their application ranges from drug discovery, where the effect of novel therapeutics can be studied in the context of PSMD9 deficiency, to gene therapy research, exploring ways to restore proteostasis in affected diseases.
Compared to traditional methods such as chemical inhibitors or RNA interference techniques, these knockout cell lines provide a stable, permanent model that allows for consistent experimental results across multiple studies. This offers a unique advantage in long-term research endeavors, enabling a thorough understanding of cellular phenotype changes resulting from PSMD9 loss.
For researchers and clinicians aiming to uncover the complexities of protein regulation and its effects on health and disease, PSMD9 Gene Knockout Cell Lines are an essential tool in advancing scientific knowledge. Our company specializes in providing high-quality genetic tools designed to meet rigorous research standards, ensuring reliability and reproducibility in every application. Embrace the potential of innovative genetic solutions with our expertly developed PSMD9 Gene Knockout Cell Lines and unlock new horizons in your scientific exploration.
Please note that all services are for research use only. Not intended for any clinical use.
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