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PSMC3IP Knockout Cell Lines

Gene: PSMC3IP

Official Full Name: PSMC3 interacting proteinprovided by HGNC

Gene Summary: This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26983 PSMC3IP Knockout cell line (HeLa) Human PSMC3IP 1:3~1:6 Negative Online Inquiry
KO26984 PSMC3IP Knockout cell line (HCT 116) Human PSMC3IP 1:2~1:4 Negative Online Inquiry
KO26985 PSMC3IP Knockout cell line (HEK293) Human PSMC3IP 1:3~1:6 Negative Online Inquiry
KO26986 PSMC3IP Knockout cell line (A549) Human PSMC3IP 1:3~1:4 Negative Online Inquiry

Background

PSMC3IP Gene Knockout Cell Lines are advanced biological research tools specifically designed for studying the functional roles of the PSMC3IP gene, which is implicated in various cellular processes, including proteostasis and responses to cellular stress. These cell lines have been engineered using state-of-the-art CRISPR/Cas9 gene-editing technology to create stable knockout models, enabling precise investigation of the gene's contribution to protein homeostasis and its potential links to diseases such as cancer and neurodegeneration.

The key mechanism behind the functionality of these knockout cell lines lies in the complete disruption of PSMC3IP expression, allowing researchers to assess the resultant phenotypic changes and signaling pathways altered in its absence. By providing an authentic biological model, these cell lines facilitate in-depth analysis of the gene’s role, thus enhancing our understanding of its involvement in pathophysiological processes.

The scientific importance of PSMC3IP Gene Knockout Cell Lines transcends basic research; they are invaluable in drug discovery, biomarker validation, and therapeutic target identification. Their application can lead to new insights that are critical for advancing the development of targeted therapies and personalized medicine.

What sets PSMC3IP Gene Knockout Cell Lines apart from conventional models is their high specificity and the reproducibility of results. Unlike other genetically modified cell lines that might display residual activity of the gene, these knockout lines ensure a complete gene depletion, yielding more accurate observations. Furthermore, they are available through a streamlined process, allowing for quicker integration into research workflows.

For researchers and clinicians focused on the intricacies of cellular mechanisms and disease pathology, utilizing PSMC3IP Gene Knockout Cell Lines translates to improved experimental reliability and the potential for groundbreaking discoveries. Our company is dedicated to providing high-quality biological products, backed by years of expertise in gene editing technologies. This commitment ensures that our customers receive the most innovative and effective tools to propel their research forward.

Please note that all services are for research use only. Not intended for any clinical use.

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