Home / PSAP Knockout Cell Lines

PSAP Knockout Cell Lines

Gene: PSAP

Official Full Name: prosaposinprovided by HGNC

Gene Summary: This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00149 PSAP Knockout cell line (HEK293) Human PSAP 1:3~1:6 Negative Online Inquiry
KO03377 PSAP Knockout cell line (HeLa) Human PSAP 1:3~1:6 Negative Online Inquiry
KO03378 PSAP Knockout cell line (HCT 116) Human PSAP 1:2~1:4 Negative Online Inquiry
KO03379 PSAP Knockout cell line (A549) Human PSAP 1:3~1:4 Negative Online Inquiry

Background

PSAP Gene Knockout Cell Lines are engineered cell lines specifically designed to study the functional role of the PSAP gene, which encodes the prosaposin protein, a crucial component involved in lysosomal function and lipid metabolism. These knockout cell lines are generated using advanced CRISPR/Cas9 technology, allowing for precise deletion of the PSAP gene, thereby facilitating in-depth analysis of its biological effects on cellular pathways and disease mechanisms.

The key function of PSAP Gene Knockout Cell Lines lies in their ability to elucidate the consequences of PSAP deficiency on cellular homeostasis and metabolism. When the PSAP gene is inactivated, researchers can examine alterations in lysosomal enzyme activity, lipid accumulation, and the subsequent impact on cellular stress responses. This makes these cell lines invaluable for research on disease models such as Gaucher disease, Krabbe disease, and other lysosomal storage disorders that are linked to altered PSAP function.

In scientific research and clinical applications, understanding the role of PSAP enables investigators to develop potential therapeutic strategies and targeted treatments for various metabolic disorders. By utilizing PSAP Gene Knockout Cell Lines, researchers can assess the efficacy of novel compounds aimed at reversing the effects of PSAP deficiency, providing critical insights into drug discovery and development.

What sets our PSAP Gene Knockout Cell Lines apart from alternatives is their high specificity and reliability. Each cell line undergoes rigorous validation to confirm complete gene knockout and retain normal cellular characteristics, ensuring that research data generated is robust and reproducible. Additionally, our expert team provides comprehensive support and protocol optimization guidance, enhancing user experience and experimental outcomes.

For researchers and clinicians focused on lipid metabolism and lysosomal function, our PSAP Gene Knockout Cell Lines represent a unique tool that can drive innovation in the field. With our commitment to providing high-quality biological products and expertise in gene editing technologies, we aim to empower scientific discovery and contribute significantly to advancing healthcare solutions.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.