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PRKRA Knockout Cell Lines

Gene: PRKRA

Official Full Name: protein activator of interferon induced protein kinase EIF2AK2provided by HGNC

Gene Summary: This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01859 PRKRA Knockout cell line (HeLa) Human PRKRA 1:3~1:6 Negative Online Inquiry
KO01860 PRKRA Knockout cell line (HCT 116) Human PRKRA 1:2~1:4 Negative Online Inquiry
KO01861 PRKRA Knockout cell line (HEK293) Human PRKRA 1:3~1:6 Negative Online Inquiry
KO01862 PRKRA Knockout cell line (A549) Human PRKRA 1:3~1:4 Negative Online Inquiry

Background

PRKRA Gene Knockout Cell Lines are genetically engineered cell lines designed to entirely disrupt the expression of the PRKRA gene, which encodes for the protein PACT (proteins that activate interferon in response to viral infections). The central function of these knockout cell lines is to provide researchers with a robust experimental tool to investigate the role of PACT in cellular pathways, particularly those related to antiviral responses and cellular stress mechanisms. By utilizing CRISPR/Cas9 technology to achieve precise gene knockout, these cell lines facilitate comprehensive studies on how PACT influences cellular signaling and immune responses under various stress conditions.

The scientific significance of PRKRA Gene Knockout Cell Lines is profound, especially in areas such as virology, immunology, and cancer research. In research settings, these cell lines can be pivotal for elucidating PACT's function in triggering the apoptotic cascade and modulating the immune response. Clinicians can also leverage these cell lines for translational research aimed at developing novel therapeutic strategies targeting viral infections and certain malignancies.

Compared to conventional wild-type cell lines, which may exhibit confounding variability due to express PACT, our PRKRA Gene Knockout Cell Lines offer a clear advantage: they provide a controlled environment to uncover the specific contributions of this critical gene. This specificity leads to more reliable and reproducible experimental results, thus accelerating the pace of discovery.

The value of PRKRA Gene Knockout Cell Lines to researchers and clinicians lies not only in their ability to simplify studies of gene function but also in their potential to foster the development of innovative treatments and interventions. Our company, with its expertise in genetic engineering and commitment to high-quality biological products, stands behind the efficacy of these cell lines as essential tools in cutting-edge research and clinical applications. By providing these uniquely valuable resources, we aim to empower the scientific community to make significant advancements in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

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