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PRKCSH Knockout Cell Lines

Gene: PRKCSH

Official Full Name: PRKCSH beta subunit of glucosidase IIprovided by HGNC

Gene Summary: This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05296 PRKCSH Knockout cell line (HeLa) Human PRKCSH 1:3~1:6 Negative Online Inquiry
KO05297 PRKCSH Knockout cell line (HCT 116) Human PRKCSH 1:2~1:4 Negative Online Inquiry
KO05298 PRKCSH Knockout cell line (HEK293) Human PRKCSH 1:3~1:6 Negative Online Inquiry
KO05299 PRKCSH Knockout cell line (A549) Human PRKCSH 1:3~1:4 Negative Online Inquiry

Background

PRKCSH Gene Knockout Cell Lines represent a significant advancement in cellular biology and genetic research, specifically designed to study the function of the PRKCSH gene within mammalian cells. These specialized cell lines have undergone precise genetic modification to disrupt the expression of the PRKCSH gene, which encodes the protein that plays a critical role in various cellular processes, including signal transduction and cell metabolism. By eliminating PRKCSH expression, researchers can gain insights into the gene's involvement in diseases, particularly in the context of cancer and metabolic disorders.

The key function of PRKCSH gene knockout cell lines lies in their mechanism of action, which allows scientists to observe changes in cellular processes resultant from the absence of this gene. This includes alterations in cell proliferation, response to growth factors, and metabolic pathways, significantly contributing to the understanding of how PRKCSH influences both normal physiology and pathological states.

The scientific importance of utilizing PRKCSH gene knockout cell lines is profound; they serve as invaluable tools in both basic research and clinical settings, enabling researchers to investigate gene function, test pharmacological agents, and develop therapeutic strategies targeting PRKCSH-associated diseases. With an increasingly pressing need for more sophisticated models that accurately mimic human cellular behavior, these cell lines stand at the forefront of genetic research.

What sets PRKCSH gene knockout cell lines apart from alternatives is their specificity and reliability, derived from stringent validation processes. Unlike conventional cell lines, these knockout models exhibit a well-characterized genetic background, ensuring reproducibility and consistency across experiments, which diminishes the variability often encountered with other systems. Furthermore, the availability of a comprehensive characterization data set enhances their appeal to researchers seeking to understand the mechanistic underpinnings of specific biological processes.

Ultimately, PRKCSH gene knockout cell lines present a unique and valuable resource for researchers and clinicians striving to uncover the complexities of gene function and disease pathology. With a commitment to innovation and quality, our company brings forth products that align with the highest scientific standards, equipping the research community with tools that advance knowledge and foster the development of effective therapies.

Please note that all services are for research use only. Not intended for any clinical use.

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