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PRKAA1 Knockout Cell Lines

Gene: PRKAA1

Official Full Name: protein kinase AMP-activated catalytic subunit alpha 1provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00557 PRKAA1 Knockout cell line (A549) Human PRKAA1 1:3~1:4 Negative Online Inquiry
KO01029 PRKAA1 Knockout cell line (HEK293) Human PRKAA1 1:3~1:6 Negative Online Inquiry
KO01384 PRKAA1 Knockout cell line (HeLa) Human PRKAA1 1:3~1:6 Negative Online Inquiry
KO10164 PRKAA1 Knockout cell line (HCT 116) Human PRKAA1 1:2~1:4 Negative Online Inquiry

Background

PRKAA1 Gene Knockout Cell Lines are genetically engineered cellular models designed to eliminate the expression of the PRKAA1 gene, which encodes the alpha subunit of AMP-activated protein kinase (AMPK). AMPK plays a pivotal role in cellular energy homeostasis, sensing cellular energy levels, and regulating metabolic processes. By creating knockout cell lines, researchers can study the specific functions and pathways influenced by PRKAA1, shedding light on metabolic diseases, cancer biology, and cellular stress responses.

The primary function of PRKAA1 Gene Knockout Cell Lines is to facilitate the examination of altered signaling pathways when AMPK activity is inhibited. These cell lines can be utilized to investigate how the loss of AMPK influences vital cellular processes such as autophagy, glucose metabolism, and lipid metabolism. This insight is crucial for understanding conditions like obesity, type 2 diabetes, and various cancers, where AMPK signaling is often dysregulated.

The scientific importance of this product is underscored by its broad applications in both basic research and potential clinical settings. Researchers can leverage these knockout models to identify novel therapeutic targets, understand drug mechanisms, and explore the role of energy balance in disease progression. The development of targeted therapy strategies becomes feasible with insights gained from these models, connecting basic research to future therapeutic interventions.

What sets PRKAA1 Gene Knockout Cell Lines apart from alternative models is their precision and reliability. Traditional methods of gene manipulation often result in off-target effects or incomplete gene disruptions, whereas our knockout cell lines provide a definitive and reproducible approach to studying specific gene functions. This high level of specificity not only increases the confidence in experimental results but also reduces the time and resources spent on troubleshooting non-specific disruptions.

The value of PRKAA1 Gene Knockout Cell Lines lies in their ability to provide researchers and clinicians with pivotal insights into energy metabolism and its related disorders. By utilizing these advanced models, scientists can accelerate the pace of discovery, improve the translational potential of their findings, and develop more effective strategies for disease management.

At [Company Name], we pride ourselves on our cutting-edge genetic engineering technologies and our commitment to providing innovative solutions for the scientific community. Our expertise ensures that our knockout cell lines are of the highest quality, readily applicable to a wide array of research questions, and designed to support your groundbreaking work in biological science.

Please note that all services are for research use only. Not intended for any clinical use.

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