Gene: PRDX3
Official Full Name: peroxiredoxin 3provided by HGNC
Gene Summary: This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31401 | PRDX3 Knockout cell line (HeLa) | Human | PRDX3 | 1:3~1:6 | Negative | Online Inquiry |
KO31402 | PRDX3 Knockout cell line (HCT 116) | Human | PRDX3 | 1:2~1:4 | Negative | Online Inquiry |
KO31403 | PRDX3 Knockout cell line (HEK293) | Human | PRDX3 | 1:3~1:6 | Negative | Online Inquiry |
KO31404 | PRDX3 Knockout cell line (A549) | Human | PRDX3 | 1:3~1:4 | Negative | Online Inquiry |
PRDX3 Gene Knockout Cell Lines are innovative cell models specifically engineered to lack the expression of the peroxiredoxin 3 (PRDX3) gene, which plays a pivotal role in regulating cellular oxidative stress responses. These knockout lines provide researchers with a powerful tool to investigate the biological implications of PRDX3 loss, including its effects on mitochondrial function, reactive oxygen species (ROS) metabolism, and cellular signaling pathways.
Functionally, PRDX3 is an antioxidant enzyme that assists in reducing hydrogen peroxide and other peroxide species within mitochondria, safeguarding the integrity of cellular components and influencing apoptotic processes. By utilizing PRDX3 Gene Knockout Cell Lines, scientists can elucidate the mechanistic pathways involved in oxidative stress-related diseases, such as neurodegenerative disorders and cancer, creating opportunities for targeted therapeutic interventions.
The scientific importance of these cell lines extends into various research and clinical settings, offering invaluable insights into mitochondrial dynamics and cellular aging. Researchers can conduct high-throughput screenings, drug responsiveness tests, and metabolic profiling with these models, enhancing the understanding of disease mechanisms and potential treatments.
One of the key advantages of PRDX3 Gene Knockout Cell Lines is their specificity and reproducibility in experiments, enabling accurate comparisons with wild-type cells. Compared to other models, these cell lines eliminate confounding factors associated with gene variability, facilitating precise data collection and interpretation.
For researchers and clinicians committed to advancing studies in oxidative stress, mitochondrial biology, and related pathologies, PRDX3 Gene Knockout Cell Lines are indispensable. They provide a reliable framework for hypothesis testing and experimental validation, ultimately supporting advancements in both basic and applied biosciences.
With a strong background in developing specialized cellular models, our company is dedicated to delivering high-quality biological products tailored to meet the needs of the scientific community. We pride ourselves on our commitment to innovation, quality, and supporting researchers in their quest for knowledge and discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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