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PRDM15 Knockout Cell Lines

Gene: PRDM15

Official Full Name: PR/SET domain 15provided by HGNC

Gene Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II; regulation of signal transduction; and regulation of stem cell division. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20155 PRDM15 Knockout cell line (HeLa) Human PRDM15 1:3~1:6 Negative Online Inquiry
KO20156 PRDM15 Knockout cell line (HCT 116) Human PRDM15 1:2~1:4 Negative Online Inquiry
KO20157 PRDM15 Knockout cell line (HEK293) Human PRDM15 1:3~1:6 Negative Online Inquiry
KO20158 PRDM15 Knockout cell line (A549) Human PRDM15 1:3~1:4 Negative Online Inquiry

Background

PRDM15 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to facilitate the investigation of the PRDM15 gene and its associated biological functions. By utilizing CRISPR-Cas9 technology, these cell lines have been rendered deficient in PRDM15 expression, enabling researchers to dissect its role in various cellular contexts, including pluripotency, differentiation, and cellular reprogramming.

The key mechanism by which PRDM15 Gene Knockout Cell Lines operate is through the targeted disruption of the PRDM15 gene. This knockout leads to the loss of the PRDM15 protein, a transcriptional regulator implicated in several critical processes including embryonic stem cell maintenance, development, and epigenetic regulation. The ability to manipulate this gene allows scientists to observe the phenotypic and functional consequences resulting from its absence, thus providing insights into its biological significance.

The scientific importance of using these knockout cell lines lies in their application in both basic research and potential clinical settings. Investigating PRDM15's functions contributes to a better understanding of developmental biology and its implications in diseases such as cancer, where dysregulation of gene expression is commonly observed. Moreover, these cell lines can serve as valuable tools for drug discovery, enabling identification of novel therapeutic targets.

One unique advantage of PRDM15 Gene Knockout Cell Lines is their specificity and reliability compared to traditional gene silencing methods like RNA interference, which may produce off-target effects. Additionally, the verification of complete knockout provides greater confidence in experimental outcomes, ensuring the reproducibility essential for high-quality research.

These knockout cell lines are particularly valuable to researchers focused on gene regulation and developmental pathways, as they enable comprehensive functional analysis with high precision. By understanding the role of PRDM15, researchers can unveil new avenues for therapeutic interventions in regenerative medicine and disease modeling.

Our company specializes in providing cutting-edge biological research tools, including gene knockout models that meet rigorous scientific standards. We are committed to supporting the research community with products that enable groundbreaking discoveries in the field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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