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PPP2R2D Knockout Cell Lines

Gene: PPP2R2D

Official Full Name: protein phosphatase 2 regulatory subunit Bdeltaprovided by HGNC

Gene Summary: Predicted to enable enzyme-substrate adaptor activity and protein phosphatase regulator activity. Predicted to be involved in exit from mitosis and regulation of chromosome segregation. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08585 PPP2R2D Knockout cell line (HeLa) Human PPP2R2D 1:3~1:6 Negative Online Inquiry
KO08586 PPP2R2D Knockout cell line (HCT 116) Human PPP2R2D 1:2~1:4 Negative Online Inquiry
KO08587 PPP2R2D Knockout cell line (HEK293) Human PPP2R2D 1:3~1:6 Negative Online Inquiry
KO08588 PPP2R2D Knockout cell line (A549) Human PPP2R2D 1:3~1:4 Negative Online Inquiry

Background

PPP2R2D Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the PPP2R2D gene, which encodes one of the regulatory subunits of protein phosphatase 2A (PP2A). This gene plays a critical role in cellular signaling pathways, epigenetic regulation, and tumor suppression. By creating knockout models, researchers can gain insights into the functions of PPP2R2D, its interactions, and its contributions to various physiological and pathological processes, including cancer progression and cellular growth regulation.

The primary function of these knockout cell lines involves elucidating the role of the PPP2R2D gene in modulating PP2A activity, which is vital for dephosphorylating a range of substrates involved in key signaling pathways. Without the PPP2R2D subunit, researchers can observe alterations in PP2A's regulatory capacity, affording a clearer understanding of how these modifications influence cell fate, proliferation, and tumorigenesis. This mechanistic detail is imperative in both basic research and therapeutic development.

The scientific significance of PPP2R2D knockout cell lines is evident in their applications across various fields, including cancer research, drug discovery, and developmental biology. By utilizing these models, scientists can explore novel therapeutic strategies that target dysregulated phosphatase activities, ultimately contributing to personalized medicine approaches.

Compared to other cell lines with incomplete or less specific gene modifications, our PPP2R2D knockout cell lines offer a distinct advantage in their ability to induce precise genetic disruption. This specificity enhances data integrity and reproducibility, making them indispensable for accurately delineating the impacts of PPP2R2D on cellular processes.

For researchers and clinicians focused on the molecular underpinnings of disease, these knockout cell lines represent a powerful tool for advancing understanding and potential treatment pathways. They enable cutting-edge experimental designs and facilitate the discovery of novel interventions in complex signaling networks.

At [Your Company Name], we pride ourselves on our expertise in developing biologically relevant tools tailored to accelerate research advancements, ensuring that our products, including the PPP2R2D Gene Knockout Cell Lines, deliver exceptional quality and reliability for scientific exploration.

Please note that all services are for research use only. Not intended for any clinical use.

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