Gene: PPP2R2C
Official Full Name: protein phosphatase 2 regulatory subunit Bgammaprovided by HGNC
Gene Summary: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08589 | PPP2R2C Knockout cell line (HeLa) | Human | PPP2R2C | 1:3~1:6 | Negative | Online Inquiry |
KO08590 | PPP2R2C Knockout cell line (HCT 116) | Human | PPP2R2C | 1:2~1:4 | Negative | Online Inquiry |
KO08591 | PPP2R2C Knockout cell line (HEK293) | Human | PPP2R2C | 1:3~1:6 | Negative | Online Inquiry |
KO08592 | PPP2R2C Knockout cell line (A549) | Human | PPP2R2C | 1:3~1:4 | Negative | Online Inquiry |
PPP2R2C Gene Knockout Cell Lines represent an essential tool for biological research, designed to facilitate the study of the PPP2R2C gene's role in cellular processes, particularly in the context of signal transduction and cell cycle regulation. These cell lines are engineered to disable the PPP2R2C gene, which encodes a regulatory subunit of Protein Phosphatase 2A (PP2A), a pivotal enzyme involved in numerous cellular signaling pathways.
The primary function of these knockout cell lines is to provide insights into the biological implications of PPP2R2C loss. By observing the phenotypic changes and signaling alterations in these cells, researchers can delve deeply into the implications of altered PP2A activity, including its relationships with oncogenesis, tumor progression, and cell apoptosis. The knockout mechanism relies on CRISPR/Cas9 technology, allowing for precise gene editing, which enhances the reliability of data obtained from experiments using these lines.
The scientific importance of PPP2R2C Gene Knockout Cell Lines cannot be overstated, as they contribute to a growing body of knowledge regarding cancer biology and therapeutic target identification. These cell lines are especially valuable in drug discovery phases and preclinical testing, where understanding the role of specific genes in cellular responses to therapeutic agents is vital.
Compared to traditional research methodologies, these knockout cell lines offer a more robust and reliable framework, reducing the variable factors that can confound experimental results. Moreover, they are specifically engineered for reproducibility and ease of use, which signifies a competitive edge over alternatives such as transient transfection methods that may result in inconsistent expression levels.
For researchers and clinicians, the PPP2R2C Gene Knockout Cell Lines present a unique opportunity to advance our understanding of crucial signaling pathways in disease contexts, ultimately aiding in the development of targeted therapies. Our company prides itself on delivering high-quality, rigorously validated biological products that empower scientists to answer their most challenging questions, ensuring that you have the tools necessary for groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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