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PPP2R2A Knockout Cell Lines

Gene: PPP2R2A

Official Full Name: protein phosphatase 2 regulatory subunit Balphaprovided by HGNC

Gene Summary: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01378 PPP2R2A Knockout cell line (HeLa) Human PPP2R2A 1:3~1:6 Negative Online Inquiry
KO10190 PPP2R2A Knockout cell line (HCT 116) Human PPP2R2A 1:2~1:4 Negative Online Inquiry
KO10191 PPP2R2A Knockout cell line (HEK293) Human PPP2R2A 1:3~1:6 Negative Online Inquiry
KO10192 PPP2R2A Knockout cell line (A549) Human PPP2R2A 1:3~1:4 Negative Online Inquiry

Background

PPP2R2A Gene Knockout Cell Lines are specialized genetic models designed to study the role of the PPP2R2A gene, which encodes a regulatory subunit of protein phosphatase 2A (PP2A). This essential phosphatase is involved in numerous cellular processes, including cell division, differentiation, and signal transduction pathways. By creating knockout cell lines that lack the functional PPP2R2A gene, researchers can directly observe the effects of its absence on cellular behavior, protein interactions, and disease mechanisms.

The primary function of these knockout cell lines is to provide a clear system for dissecting the cellular pathways governed by PP2A regulation. By knocking out the PPP2R2A gene, it becomes possible to elucidate the downstream effects on critical pathways such as the MAPK signaling cascade and the regulation of cell cycle progression. Utilizing these cell lines allows for targeted investigations that can advance our understanding of various disorders, including cancer, neurodegenerative diseases, and metabolic syndromes, where aberrant PP2A activity is implicated.

From a scientific and clinical perspective, the PPP2R2A Gene Knockout Cell Lines present invaluable opportunities to explore therapeutic strategies aimed at restoring normal PP2A function. They are particularly important in drug discovery and the validation of potential compounds that can modulate the activity of PP2A, thereby offering avenues for novel treatment protocols.

These cell lines stand out in the market due to their ease of use and reproducibility. Unlike traditional models that may involve complex genetic engineering processes, our knockout cell lines come with guaranteed genetic modification and robust characterization, ensuring consistency and reliability in experimental outcomes.

For researchers and clinicians, the PPP2R2A Gene Knockout Cell Lines are crucial tools for advancing our understanding of phosphatase biology and its implications in health and disease. Our company, with its dedication to high-quality biological products and extensive experience in genetic engineering, is proud to offer these innovative cell lines that facilitate cutting-edge research and contribute to significant breakthroughs in biomedical science.

Please note that all services are for research use only. Not intended for any clinical use.

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