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PPP1R13L Knockout Cell Lines

Gene: PPP1R13L

Official Full Name: protein phosphatase 1 regulatory subunit 13 likeprovided by HGNC

Gene Summary: IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01518 PPP1R13L Knockout cell line (HeLa) Human PPP1R13L 1:3~1:6 Negative Online Inquiry
KO01519 PPP1R13L Knockout cell line (HCT 116) Human PPP1R13L 1:2~1:4 Negative Online Inquiry
KO01520 PPP1R13L Knockout cell line (HEK293) Human PPP1R13L 1:3~1:6 Negative Online Inquiry
KO01521 PPP1R13L Knockout cell line (A549) Human PPP1R13L 1:3~1:4 Negative Online Inquiry

Background

PPP1R13L Gene Knockout Cell Lines are genetically engineered cell lines in which the expression of the PPP1R13L gene has been disrupted to study its biological functions and implications in cellular processes. These knockout cell lines utilize CRISPR-Cas9 technology to introduce targeted mutations that effectively eliminate the gene's coding sequence. The primary function of these cell lines is to serve as valuable models for investigating the role of PPP1R13L in cellular signaling, apoptosis, and immune responses, thus enhancing our understanding of its contribution to diseases such as cancer and neurodegenerative disorders.

In scientific research and clinical settings, these knockout cell lines provide an essential tool for elucidating the molecular mechanisms underlying various pathologies. By analyzing the changes in cellular behavior and gene expression profiles following the loss of PPP1R13L, researchers can identify potential therapeutic targets and biomarkers. Furthermore, these models allow for the evaluation of drug responses and the study of phenotype alterations in a controlled environment, leading to more robust preclinical data.

Compared to traditional gene knockdown approaches, such as RNA interference, PPP1R13L knockout cell lines deliver a more permanent and defined disruption of gene function, ensuring reproducibility and reliability in experiments. This permanence grants researchers a clearer insight into the gene's role without the confounding effects of transient expression, a common drawback in other methodologies.

For researchers and clinicians focused on gene function studies, this product offers a unique advantage by facilitating innovative experimental designs that can accelerate the progress of fundamental and translational research. As a leading provider of advanced biological tools, our company is committed to delivering high-quality and reliable products like the PPP1R13L Gene Knockout Cell Lines, ensuring users can confidently explore and unlock the complexities of biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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