Gene: PPIH
Official Full Name: peptidylprolyl isomerase Hprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06172 | PPIH Knockout cell line (HeLa) | Human | PPIH | 1:3~1:6 | Negative | Online Inquiry |
KO06173 | PPIH Knockout cell line (HCT 116) | Human | PPIH | 1:2~1:4 | Negative | Online Inquiry |
KO06174 | PPIH Knockout cell line (HEK293) | Human | PPIH | 1:3~1:6 | Negative | Online Inquiry |
KO06175 | PPIH Knockout cell line (A549) | Human | PPIH | 1:3~1:4 | Negative | Online Inquiry |
PPIH Gene Knockout Cell Lines are specially engineered cell lines in which the PPIH (peptidylprolyl isomerase H) gene has been selectively disrupted. This innovative biological product is designed to facilitate the study of PPIH's role in various cellular processes, including protein folding and regulation of molecular chaperones, thereby enhancing our understanding of its function in disease mechanisms and potential therapeutic targets.
These cell lines utilize the CRISPR-Cas9 technology to create specific gene knockouts, allowing for thorough investigation of phenotypic alterations in cholesterol metabolism, cellular stress responses, and apoptosis, among other critical biological functions. The knockout mechanism ensures that researchers can observe the direct impact of the loss of PPIH expression on cellular behavior, enabling the elucidation of pathways that may be compromised in pathological states.
The scientific importance of PPIH Gene Knockout Cell Lines is particularly pronounced in biomedical research, where they serve as powerful tools for drug discovery, target validation, and functional genomics. Additionally, their applications extend to understanding human diseases, including cancer and neurodegenerative disorders, where PPIH's role is increasingly recognized.
One of the standout advantages of these cell lines is their precision and reproducibility, reducing variability often seen in traditional knockout methods. Furthermore, PPIH Gene Knockout Cell Lines come with comprehensive supporting data, including characterization and verification, to ensure researchers can trust the integrity of their experimental results.
For researchers and clinicians invested in molecular biology and therapeutic developments, these cell lines represent a valuable resource for probing the intricate biological functions of PPIH. Their availability can accelerate the pace of discovery, ultimately paving the way for novel interventions in clinical practice.
Our company specializes in genetic engineering and cell line development, providing high-quality biological tools like the PPIH Gene Knockout Cell Lines. With a commitment to advancing research, we supply innovative solutions that empower scientists in their pursuit of understanding complex biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
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