Gene: PPFIA1
Official Full Name: PTPRF interacting protein alpha 1provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34122 | PPFIA1 Knockout cell line (HeLa) | Human | PPFIA1 | 1:3~1:6 | Negative | Online Inquiry |
KO34123 | PPFIA1 Knockout cell line (HCT 116) | Human | PPFIA1 | 1:2~1:4 | Negative | Online Inquiry |
KO34124 | PPFIA1 Knockout cell line (HEK293) | Human | PPFIA1 | 1:3~1:6 | Negative | Online Inquiry |
KO34125 | PPFIA1 Knockout cell line (A549) | Human | PPFIA1 | 1:3~1:4 | Negative | Online Inquiry |
PPFIA1 Gene Knockout Cell Lines are genetically engineered cell models that have been specifically designed to facilitate the study of the PPFIA1 gene, which encodes a protein involved in various cellular processes, including synaptic signaling and cytoskeletal dynamics. By creating knockout cell lines, which lack the expression of the PPFIA1 gene, researchers can investigate the gene's role in cellular function, disease processes, and therapeutic responses.
These cell lines function as vital tools in experimental setups, enabling scientists to elucidate pathways influenced by PPFIA1 and understand its implications in neurobiology and cancer research. The mechanism behind their utility lies in their ability to mimic conditions of gene silencing, allowing for in-depth investigation into the pathological roles that the PPFIA1 protein may play and offering insights that are often not achievable with wild-type cells.
The scientific importance of PPFIA1 knockout cell lines extends to both basic and applied research contexts. Clinically, they offer potential insights into therapeutic interventions for diseases where PPFIA1 misregulation is implicated, such as certain neurodevelopmental disorders and malignant tumor progression. Researchers can leverage these models to test drug efficacy, assess gene therapy approaches, and screen for small molecules that may modulate PPFIA1-related pathways.
What sets our PPFIA1 Gene Knockout Cell Lines apart from alternative models is their reliability, reproducibility, and the thorough characterization provided, ensuring that users obtain consistent results. In addition, our commitment to quality means that these cell lines are rigorously validated and characterized, supported by comprehensive protocols and technical support.
For researchers and clinicians focused on unraveling the complexities of gene function, these knockout cell lines are invaluable. They not only streamline experimental design but also provide a clearer understanding of gene interactions in biological systems. With our extensive expertise in genetic engineering and cell line development, we deliver cutting-edge products that enhance the research capabilities of our customers, fostering advancements in the life sciences field.
Please note that all services are for research use only. Not intended for any clinical use.
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