Gene: PPARD
Official Full Name: peroxisome proliferator activated receptor deltaprovided by HGNC
Gene Summary: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11705 | PPARD Knockout cell line (HeLa) | Human | PPARD | 1:3~1:6 | Negative | Online Inquiry |
KO11706 | PPARD Knockout cell line (HCT 116) | Human | PPARD | 1:2~1:4 | Negative | Online Inquiry |
KO11707 | PPARD Knockout cell line (HEK293) | Human | PPARD | 1:3~1:6 | Negative | Online Inquiry |
KO11708 | PPARD Knockout cell line (A549) | Human | PPARD | 1:3~1:4 | Negative | Online Inquiry |
PPARD Gene Knockout Cell Lines are engineered cellular models that have undergone a specific gene deletion of the peroxisome proliferator-activated receptor delta (PPARD) gene. This biological product serves as an invaluable tool for researchers studying metabolic disorders, inflammation, and various cancer processes, as PPARD is implicated in the regulation of glucose metabolism, lipid homeostasis, and cell proliferation.
These cell lines operate through the absence of the PPARD transcription factor, which typically regulates gene expression involved in fatty acid metabolism and energy expenditure. By knocking out this gene, researchers can directly study the phenotypic consequences of diminished PPARD activity, thus elucidating its role in metabolic pathways and disease states. The knockout lines enable the investigation of mechanisms underlying metabolic dysregulation, aiding the development of targeted therapeutics to address conditions like diabetes and obesity.
The scientific importance of PPARD Gene Knockout Cell Lines extends to their applications in both research and clinical laboratories. Their use provides insights into how the absence of this receptor can influence drug responses and disease progression, paving the way for novel therapeutic strategies. Compared to traditional wild-type cell lines, these knockout models offer a more precise avenue for exploring PPARD-related pathways without the confounding influences of normal receptor function.
Key advantages of PPARD Gene Knockout Cell Lines include their reproducibility, consistency in experimental settings, and the potential for application across various biological research fields, such as pharmacology, endocrinology, and cancer biology. This unique offering allows researchers and clinicians to harness the specificity of gene knockout techniques to drive discoveries in health and disease.
In a landscape where understanding molecular mechanisms is crucial, our PPARD Gene Knockout Cell Lines deliver unparalleled quality and reliability. As a company dedicated to cutting-edge research, we pride ourselves on providing products that empower scientists in their quest for breakthroughs and enhanced therapies.
Please note that all services are for research use only. Not intended for any clinical use.
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