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POR Knockout Cell Lines

Gene: POR

Official Full Name: cytochrome p450 oxidoreductaseprovided by HGNC

Gene Summary: This gene encodes an endoplasmic reticulum membrane oxidoreductase that is essential for multiple metabolic processes, including reactions catalyzed by cytochrome P450 proteins for metabolism of steroid hormones, drugs and xenobiotics. The encoded protein has a flavin adenine dinucleotide (FAD)-binding domain and a flavodoxin-like domain which bind two cofactors, FAD and FMN, that allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene cause a complex set of disorders, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome, that resemble those caused by defects in steroid metabolizing enzymes such as aromatase, 21-hydroxylase, and 17 alpha-hydroxylase. [provided by RefSeq, Aug 2020]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02182 POR Knockout cell line (HeLa) Human POR 1:3~1:6 Negative Online Inquiry
KO02183 POR Knockout cell line (HCT 116) Human POR 1:2~1:4 Negative Online Inquiry
KO02184 POR Knockout cell line (HEK293) Human POR 1:3~1:6 Negative Online Inquiry
KO02185 POR Knockout cell line (A549) Human POR 1:3~1:4 Negative Online Inquiry

Background

POR Gene Knockout Cell Lines are genetically modified cell lines that have been specifically engineered to lack the expression of the POR gene (P450 oxidoreductase). This essential enzyme plays a pivotal role in the electron transfer necessary for the metabolism of a variety of xenobiotics and endogenous compounds, including steroid hormones and drugs. By utilizing these knockout cell lines, researchers are equipped with a powerful tool to investigate the specific role of the POR gene in biochemical pathways, drug metabolism, and cellular responses to various treatments.

The primary mechanism by which POR Gene Knockout Cell Lines function is through the complete absence of the POR enzyme, allowing for the dissection of its contributions to metabolic pathways. Researchers can examine alterations in metabolic activity, pathway regulation, and cellular responses associated with the absence of POR, providing insights into how these processes are regulated by or depend on this important gene. This cellular model aids in understanding drug interactions, the impacts of genetic variability on metabolism, and informs safety assessments in pharmacology.

In research and clinical settings, POR Gene Knockout Cell Lines hold significant scientific importance. They are invaluable for pharmacological studies that evaluate how the lack of POR affects drug efficacy and toxicity. Furthermore, they facilitate the study of metabolic disorders, allowing researchers to explore genetic predispositions to diseases and personalize medicine approaches.

Compared to alternative models that may not completely eliminate POR function, these knockout cell lines provide a specific and controlled environment for rigorous testing and observation. They offer enhanced accuracy in experimental results, reducing variability caused by incomplete gene silencing.

The value of POR Gene Knockout Cell Lines extends beyond mere research; they serve as a foundation for innovative therapeutic strategies and drug development processes. Researchers and clinicians can directly observe cellular responses that inform treatment protocols and lead to improved patient outcomes.

At [Your Company Name], we pride ourselves on our expertise in providing cutting-edge genetic models and ensuring that our products meet the highest standards of scientific reliability. Our commitment to advancing biological research through precision genetic engineering positions our POR Gene Knockout Cell Lines as essential tools for trailblazing advancements in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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