Gene: PLEKHA7
Official Full Name: pleckstrin homology domain containing A7provided by HGNC
Gene Summary: Enables delta-catenin binding activity. Involved in epithelial cell-cell adhesion; pore complex assembly; and zonula adherens maintenance. Located in several cellular components, including centrosome; nucleoplasm; and zonula adherens. Part of pore complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24135 | PLEKHA7 Knockout cell line (HeLa) | Human | PLEKHA7 | 1:3~1:6 | Negative | Online Inquiry |
KO24136 | PLEKHA7 Knockout cell line (HCT 116) | Human | PLEKHA7 | 1:2~1:4 | Negative | Online Inquiry |
KO24137 | PLEKHA7 Knockout cell line (HEK293) | Human | PLEKHA7 | 1:3~1:6 | Negative | Online Inquiry |
KO24138 | PLEKHA7 Knockout cell line (A549) | Human | PLEKHA7 | 1:3~1:4 | Negative | Online Inquiry |
PLEKHA7 Gene Knockout Cell Lines are genetically engineered cellular models that have undergone precise gene disruption of the PLEKHA7 gene, crucial in various cellular processes such as cell signaling, adhesion, and polarity. These cell lines serve as a powerful tool for researchers aiming to dissect the functional roles of PLEKHA7 in physiological and pathological contexts. The knockout technique employed in the development of these cell lines, typically utilizing CRISPR-Cas9 technology or similar methodologies, allows for the targeted and efficient inactivation of the gene, thereby providing researchers with an effective means to study loss-of-function phenotypes.
The unique mechanism behind these cell lines permits the elucidation of PLEKHA7's involvement in disease mechanisms, particularly in cancer and neurobiology, where dysregulation of cell adhesion and signaling pathways is often observed. By using PLEKHA7 knockout models, researchers can investigate how the absence of this gene influences tumor progression, cellular morphology, and response to therapeutic agents, thereby yielding insights that are invaluable in developing targeted treatment strategies.
One of the significant advantages of using PLEKHA7 Gene Knockout Cell Lines is their specificity and reproducibility compared to alternative methods, such as RNA interference, which can lead to incomplete gene silencing and off-target effects. Furthermore, these knockout lines can be utilized across a variety of cell types, offering versatility for different experimental designs, including high-throughput screening and drug validation assays.
For researchers and clinicians focusing on the molecular underpinnings of disease, these knockout cell lines represent a validated and reliable resource to further understand the PLEKHA7 gene’s contributions within their chosen field. Incorporating PLEKHA7 Gene Knockout Cell Lines into research protocols can facilitate breakthroughs in gene function studies and may pave the way for innovative therapies.
With our company’s expertise in developing advanced genetic models and a commitment to quality, we provide robust solutions that empower researchers to advance their scientific investigations. Our products are developed with precision to ensure that our customers have access to the most reliable and effective research tools available.
Please note that all services are for research use only. Not intended for any clinical use.
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