Gene: PLD3
Official Full Name: phospholipase D family member 3provided by HGNC
Gene Summary: This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02144 | PLD3 Knockout cell line (HeLa) | Human | PLD3 | 1:3~1:6 | Negative | Online Inquiry |
KO02145 | PLD3 Knockout cell line (HCT 116) | Human | PLD3 | 1:2~1:4 | Negative | Online Inquiry |
KO02146 | PLD3 Knockout cell line (HEK293) | Human | PLD3 | 1:3~1:6 | Negative | Online Inquiry |
KO02147 | PLD3 Knockout cell line (A549) | Human | PLD3 | 1:3~1:4 | Negative | Online Inquiry |
PLD3 Gene Knockout Cell Lines are genetically modified cell lines in which the PLD3 gene has been selectively deactivated, enabling researchers to study the functional consequences of its loss. These cell lines serve as critical tools for investigating the biological role of PLD3, particularly in relation to lipid metabolism and neurodegenerative diseases, given its association with Alzheimer’s disease and other cognitive disorders.
The key function of PLD3 is to encode a phospholipase D enzyme that plays an integral role in phospholipid metabolism. By generating knockout models, researchers can dissect the molecular pathways influenced by PLD3, allowing for a more comprehensive understanding of its contribution to cellular processes and disease mechanisms. This approach facilitates targeted studies on neurotransmitter release, neuronal survival, and the role of phospholipids in cellular signaling.
In scientific and clinical settings, PLD3 Gene Knockout Cell Lines have significant relevance for drug discovery and therapeutic intervention strategies. They enable the exploration of potential pharmacological agents that could modulate PLD3 activity, paving the way for innovative treatments for Alzheimer’s and other age-related disorders. Additionally, the ability to observe the phenotypic changes resulting from PLD3 inactivation has invaluable implications for advancing our knowledge of neurodegeneration.
Compared to other gene knockout systems, PLD3 Gene Knockout Cell Lines are meticulously validated, ensuring high consistency and reproducibility in experimental outcomes. They are optimized for performance, making them an attractive option for researchers seeking reliable models for their studies.
Given the increasing prioritization of understanding neurodegenerative mechanisms, PLD3 Gene Knockout Cell Lines represent a valuable addition to any research endeavor focused on brain health and disease. Our company is dedicated to providing rigorously developed biological products backed by extensive research, ensuring that researchers and clinicians have the tools they need to accelerate their discoveries and improve patient outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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