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PJA2 Knockout Cell Lines

Gene: PJA2

Official Full Name: praja ring finger ubiquitin ligase 2provided by HGNC

Gene Summary: Enables protein kinase A catalytic subunit binding activity; protein kinase A regulatory subunit binding activity; and ubiquitin protein ligase activity. Involved in several processes, including proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of macrophage activation; and regulation of signal transduction. Located in cytoplasm; cytoskeleton; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00445 PJA2 Knockout cell line (HEK293) Human PJA2 1:3~1:6 Negative Online Inquiry
KO32611 PJA2 Knockout cell line (HeLa) Human PJA2 1:3~1:6 Negative Online Inquiry
KO32612 PJA2 Knockout cell line (HCT 116) Human PJA2 1:2~1:4 Negative Online Inquiry
KO32613 PJA2 Knockout cell line (A549) Human PJA2 1:3~1:4 Negative Online Inquiry

Background

PJA2 Gene Knockout Cell Lines are specially engineered cellular models designed to study the role of the PJA2 gene in various biological contexts. By utilizing CRISPR-Cas9 technology, these cell lines have been meticulously developed to achieve targeted gene disruption, allowing researchers to investigate gene function and signaling pathways influenced by PJA2. This process involves the precise editing of the genomic DNA to create a knockout, leading to the complete absence of PJA2 protein expression and enabling a thorough examination of the downstream effects on cellular behavior and phenotype.

The key functions of the PJA2 Gene Knockout Cell Lines include facilitating the exploration of PJA2's involvement in cellular processes such as protein degradation, signal transduction, and stress responses. The knockout model offers a distinct advantage in elucidating the gene's role in diseases, particularly its implications in cancer biology and immune system regulation. Researchers can employ these cell lines to investigate novel therapeutic targets or to better understand disease mechanisms, giving them a pivotal role in both basic and translational research.

What sets the PJA2 Gene Knockout Cell Lines apart from alternatives is the combination of high specificity and reproducibility achieved through state-of-the-art gene editing techniques. Unlike traditional knockout models, which may involve multiple genetic alterations leading to off-target effects, our cell lines are validated for minimal unintended modifications, ensuring accurate results. Additionally, these lines come with comprehensive support and characterization data, enhancing their usability for researchers.

For clinicians and researchers targeting the intersection of genetics and disease treatment strategies, utilizing the PJA2 Gene Knockout Cell Lines can greatly enhance the ability to develop targeted therapies and improve patient outcomes. Our product not only provides an efficient research tool but is also backed by our company’s extensive expertise in genetic engineering and cell line development, ensuring you receive quality and reliability in your experimental work. We are dedicated to advancing scientific discovery through innovative biological products that empower researchers and clinicians alike.

Please note that all services are for research use only. Not intended for any clinical use.

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