PIP5K1C Knockout Cell Lines

PIP5K1C Gene Knockout Cell Lines represent a crucial tool in the study of phosphoinositide metabolism and its role in various cellular processes. These cell lines are genetically modified to lack the PIP5K1C gene, which encodes for phosphatidylinositol 4-phosphate 5-kinase type I gamma, an enzyme involved in the production of phosphatidylinositol 4,5-bisphosphate (PIP2). By disrupting this gene, researchers can elucidate the functional impacts of PIP2 in cellular signaling pathways, thus contributing to a deeper understanding of cell biology.

The primary function of PIP5K1C is to catalyze the phosphorylation of phosphatidylinositol 4-phosphate (PI4P) to generate PIP2, a vital component of cell membranes and a precursor for second messengers in signaling pathways. In the PIP5K1C knockout cell lines, the lack of PIP2 alters critical pathways involving cellular proliferation, migration, and apoptosis. This disruption allows scientists to investigate the roles of PIP2 in processes such as cancer development and neuronal signaling, creating a valuable platform for both basic and applied research.

The importance of these knockout cell lines extends into clinical settings, where insights gleaned from studying PIP5K1C can inform therapeutic strategies targeting various diseases, including metastatic cancers and neurological disorders. The specific advantage of utilizing PIP5K1C Gene Knockout Cell Lines lies in their capacity to provide clear evidence regarding the consequences of PIP2 depletion, which can be difficult to ascertain with other experimental approaches like pharmacological inhibition.

Researchers, clinicians, and biotechnologists seeking reliable models for studying PIP2-related pathways will find this product especially beneficial. The targeted gene knockout presents a streamlined methodology to investigate the role of phosphoinositides, which is increasingly recognized as critical in disease etiology.

Our company specializes in the development of high-quality biological products, harnessing advanced genetic engineering technologies. We are committed to delivering exceptional research tools that empower scientists to drive innovation in the life sciences. PIP5K1C Gene Knockout Cell Lines are just one exemplification of our dedication to facilitating cutting-edge research and enhancing our understanding of complex biological systems.