Gene: PIGZ
Official Full Name: phosphatidylinositol glycan anchor biosynthesis class Zprovided by HGNC
Gene Summary: The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26091 | PIGZ Knockout cell line (A549) | Human | PIGZ | 1:3~1:4 | Negative | Online Inquiry |
PIGZ Gene Knockout Cell Lines are meticulously designed cellular models that have been genetically engineered to lack the expression of the PIGZ gene, which encodes an essential protein involved in various biological pathways, including cellular metabolism and regulation of immune responses. By employing CRISPR-Cas9 technology, these cell lines provide a reliable tool for researchers looking to elucidate the role of PIGZ in cellular function and disease pathology.
The primary function of these knockout cell lines lies in their ability to facilitate the study of gene function by allowing for the observation of phenotypic changes resulting from the absence of PIGZ. Researchers can investigate downstream signaling pathways, metabolic alterations, and the cellular ramifications of gene loss. This approach enables a clearer understanding of the gene's contribution to biological processes and its potential involvement in various diseases, including metabolic disorders and cancers.
The scientific importance of PIGZ Gene Knockout Cell Lines extends to both fundamental and applied research. In clinical settings, these models can serve as platforms for drug discovery, toxicity testing, and the development of therapeutic strategies aimed at modulating PIGZ-related pathways. Their utility expands into areas such as gene editing, regenerative medicine, and personalized medicine, where understanding gene function is crucial for developing targeted interventions.
Compared to traditional cell lines that may retain gene expression, PIGZ Gene Knockout Cell Lines offer a more specific and controlled environment for the investigation of gene function, minimizing variability and enhancing reproducibility. Their robustness provides a significant advantage for high-throughput screening applications and validates experimental results with greater confidence.
For researchers and clinicians alike, the value of PIGZ Gene Knockout Cell Lines is clear: they fill a critical gap in genetic research tools, contributing invaluable insights into gene function and disease mechanisms. Our company, specializing in advanced genetic models and cellular technologies, is dedicated to providing high-quality biological products that empower scientific innovation and enhance research outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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