Gene: PHF1
Official Full Name: PHD finger protein 1provided by HGNC
Gene Summary: This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36107 | PHF1 Knockout cell line (HeLa) | Human | PHF1 | 1:3~1:6 | Negative | Online Inquiry |
KO36108 | PHF1 Knockout cell line (HCT 116) | Human | PHF1 | 1:2~1:4 | Negative | Online Inquiry |
KO36109 | PHF1 Knockout cell line (HEK293) | Human | PHF1 | 1:3~1:6 | Negative | Online Inquiry |
KO36110 | PHF1 Knockout cell line (A549) | Human | PHF1 | 1:3~1:4 | Negative | Online Inquiry |
PHF1 Gene Knockout Cell Lines are advanced biological research tools designed for the targeted study of the PHF1 gene's functions in cellular contexts. Gene knockout technology involves the deliberate inactivation or deletion of specific genes, enabling researchers to elucidate the gene's role in various biological processes, disease mechanisms, and therapeutic responses. These cell lines are meticulously engineered using CRISPR-Cas9 techniques, ensuring a precise disruption of the PHF1 gene while maintaining the overall integrity of the cellular environment.
The primary function of PHF1 Gene Knockout Cell Lines is to facilitate in-depth exploration of the physiological roles played by the PHF1 gene, which is implicated in critical biological phenomena such as epigenetic regulation and neuronal function. By utilizing these knockout models, researchers can observe phenotypic changes, signaling pathways, and transcriptional alterations caused by the absence of PHF1, thereby providing significant insights into diseases such as neurodegenerative disorders and cancers where PHF1 may play a pivotal role.
The scientific importance of these cell lines cannot be overstated, as they serve as indispensable tools in both basic and applied research. Their application spans from gene function discovery to drug screening, making them valuable assets in translational medicine and therapeutic development. Compared to alternative models, such as RNA interference or overexpression systems, the knockout approach allows for a more comprehensive understanding of gene function due to its irreversible nature.
Researchers and clinicians will find PHF1 Gene Knockout Cell Lines exceptionally beneficial due to their ability to generate clean and reproducible results, which are paramount for any form of scientific inquiry. Additionally, the versatility of these cell lines enables their integration into various experimental setups, including high-throughput screening assays, ultimately accelerating research timelines and enhancing the potential for impactful discoveries.
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Please note that all services are for research use only. Not intended for any clinical use.
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