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PGF Knockout Cell Lines

Gene: PGF

Official Full Name: placental growth factorprovided by HGNC

Gene Summary: Enables growth factor activity. Involved in positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Biomarker of several diseases, including artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); epilepsy (multiple); limited scleroderma; and pancreatic endocrine carcinoma. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10566 PGF Knockout cell line (HCT 116) Human PGF 1:2~1:4 Negative Online Inquiry
KO10567 PGF Knockout cell line (HEK293) Human PGF 1:3~1:6 Negative Online Inquiry
KO10568 PGF Knockout cell line (A549) Human PGF 1:3~1:4 Negative Online Inquiry

Background

PGF gene knockout cell lines are engineered cellular models that specifically lack the expression of the Platelet Growth Factor (PGF) gene. This innovative product is a crucial tool for scientists studying the role of PGF in various biological processes, including angiogenesis, tumor progression, and cellular signaling pathways. By utilizing CRISPR/Cas9 technology, our PGF knockout cell lines have been meticulously developed to ensure precise gene disruption and consistent phenotypic expression across batches.

The primary function of PGF gene knockout cell lines is to provide a controlled environment for examining the effects of PGF deficiency on cellular behavior, gene expression, and interactions with the extracellular matrix. Researchers can utilize these cell lines to elucidate the specific mechanisms by which PGF influences vascular biology and tumor growth, making them invaluable in navigating the complexities of related diseases.

In terms of scientific importance, PGF knockout cell lines have wide-ranging applications in both fundamental research and clinical investigations. They allow for the development of targeted therapies that aim to inhibit PGF-related pathways, particularly in oncology and regenerative medicine. By providing insights into both mechanisms of disease and potential therapeutic targets, the utility of these cell lines is unparalleled in today’s research landscape.

Among alternative products, our PGF gene knockout cell lines stand out due to their high specificity and reliability. Each line is thoroughly validated, with a robust lineage that ensures reproducibility in experiments. Furthermore, our commitment to providing comprehensive support and detailed usage protocols enhances the research experience, allowing scientists to focus on their innovative work without the added strain of troubleshooting.

For researchers and clinicians aiming to deepen their understanding of PGF's role in pathophysiology, our PGF gene knockout cell lines are an indispensable resource. Through this product offering, our company leverages extensive expertise in genetic engineering and cell biology, solidifying our position as a leader in the field of biological products tailored for transformative research.

Please note that all services are for research use only. Not intended for any clinical use.

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