Gene: PGBD1
Official Full Name: piggyBac transposable element derived 1provided by HGNC
Gene Summary: The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. This gene product is specifically expressed in the brain, however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24808 | PGBD1 Knockout cell line (HeLa) | Human | PGBD1 | 1:3~1:6 | Negative | Online Inquiry |
KO24809 | PGBD1 Knockout cell line (HCT 116) | Human | PGBD1 | 1:2~1:4 | Negative | Online Inquiry |
KO24810 | PGBD1 Knockout cell line (HEK293) | Human | PGBD1 | 1:3~1:6 | Negative | Online Inquiry |
KO24811 | PGBD1 Knockout cell line (A549) | Human | PGBD1 | 1:3~1:4 | Negative | Online Inquiry |
PGBD1 Gene Knockout Cell Lines are advanced research tools designed for the study of gene function, regulation, and associated pathways in various biological systems. These cell lines have undergone targeted gene disruption of the PGBD1 gene, which encodes the piggyBac transposase. This powerful genetic modification enables researchers to explore the roles of PGBD1 in processes such as DNA repair, genomic stability, and cellular differentiation.
The primary mechanism of these knockout cell lines involves the induction of frameshift mutations within the PGBD1 gene, effectively silencing its expression. This allows for the observation of phenotypic changes associated with the absence of PGBD1, offering insights into the gene's functional contributions. Utilizing CRISPR/Cas9 technology, researchers can achieve high specificity and efficiency in gene editing, enhancing the reliability of experimental results.
The scientific importance of PGBD1 Gene Knockout Cell Lines lies in their utility for fundamental research and potential translational applications. These cell lines serve as valuable models for studying genetic diseases, cancer biology, and developmental processes, thereby broadening our understanding of various pathophysiological conditions. Moreover, their application in drug discovery can facilitate the identification of novel therapeutic targets associated with PGBD1 dysregulation.
Compared to traditional gene knockout techniques, PGBD1 Gene Knockout Cell Lines offer unique advantages, including consistent performance, ease of use, and the ability to generate stable lines that maintain the knockout phenotype over prolonged culture periods. Furthermore, our cell lines undergo rigorous quality control and characterization to ensure optimal performance, overcoming the limitations found in alternative gene-editing platforms.
Thus, this product is invaluable to researchers and clinicians looking to deepen their understanding of genetic mechanisms or discover innovative therapeutic options. With a strong commitment to scientific advancement, our company specializes in providing high-quality biological products that empower the research community, ensuring access to cutting-edge tools essential for groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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