Gene: PDE4DIP
Official Full Name: phosphodiesterase 4D interacting proteinprovided by HGNC
Gene Summary: The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07288 | PDE4DIP Knockout cell line (HeLa) | Human | PDE4DIP | 1:3~1:6 | Negative | Online Inquiry |
KO07289 | PDE4DIP Knockout cell line (HCT 116) | Human | PDE4DIP | 1:2~1:4 | Negative | Online Inquiry |
KO07290 | PDE4DIP Knockout cell line (HEK293) | Human | PDE4DIP | 1:3~1:6 | Negative | Online Inquiry |
KO07291 | PDE4DIP Knockout cell line (A549) | Human | PDE4DIP | 1:3~1:4 | Negative | Online Inquiry |
PDE4DIP Gene Knockout Cell Lines are specifically engineered cellular models that exhibit the targeted disruption of the PDE4DIP gene, which encodes for the Phosphodiesterase 4D interacting Protein (PDE4DIP). This protein plays a critical role in cellular processes such as signal transduction, cytoskeletal dynamics, and cellular adhesion, influencing various physiological and pathological conditions. By utilizing these knockout cell lines, researchers can investigate the impact of PDE4DIP deficiency on cellular behavior, signaling pathways, and potential therapeutic targets.
The primary mechanism of action involves the use of CRISPR-Cas9 technology to induce precise genomic modifications that result in the loss of function of the PDE4DIP protein. This enables scientists to conduct detailed studies on the role of PDE4DIP in processes such as inflammation, neurodegenerative diseases, and cancer. Through these investigations, the PDE4DIP Gene Knockout Cell Lines can provide invaluable insights into cellular mechanisms and the potential for new therapeutic strategies.
The scientific significance of these knockout cell lines lies in their application across numerous research domains, including pharmacology, molecular biology, and translational medicine. Their use in studying disorders related to the dysregulation of phosphodiesterases, particularly in the context of drug discovery, positions them as a crucial tool in the quest for innovative treatments.
What sets our PDE4DIP Gene Knockout Cell Lines apart from other models is their reliability and reproducibility, which are essential for obtaining consistent experimental results. Additionally, these cell lines come with robust characterization data, enabling researchers to seamlessly integrate these models into their existing workflows.
For researchers and clinicians alike, the value of our PDE4DIP Gene Knockout Cell Lines is profound; they offer a window into understanding the complexities of cell signaling and disease mechanisms while presenting opportunities for the development of novel therapeutic interventions. Our company prides itself on its commitment to high-quality biological products backed by extensive expertise and innovation in the field, ensuring that our offerings meet the stringent needs of the contemporary research environment.
Please note that all services are for research use only. Not intended for any clinical use.
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