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PARD6A Knockout Cell Lines

Gene: PARD6A

Official Full Name: par-6 family cell polarity regulator alphaprovided by HGNC

Gene Summary: This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08665 PARD6A Knockout cell line (HeLa) Human PARD6A 1:3~1:6 Negative Online Inquiry
KO08666 PARD6A Knockout cell line (HCT 116) Human PARD6A 1:2~1:4 Negative Online Inquiry
KO08667 PARD6A Knockout cell line (HEK293) Human PARD6A 1:3~1:6 Negative Online Inquiry
KO08668 PARD6A Knockout cell line (A549) Human PARD6A 1:3~1:4 Negative Online Inquiry

Background

PARD6A Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the PARD6A gene's role in various biological processes, particularly those associated with cellular signaling and polarity. PARD6A, or Partitioning Defective 6 homolog alpha, is crucial in determining cell shape, movement, and differentiation by acting as a scaffold that links various signaling proteins. The creation of knockout cell lines, which are cells in which the PARD6A gene has been deliberately disabled, allows researchers to investigate the functional implications of this gene's absence and its involvement in diseases, including cancer and developmental disorders.

These knockout cell lines operate through a mechanism that involves the deletion of PARD6A, enabling scientists to observe the resulting cellular phenotypes and behavioral changes. Without PARD6A, cells demonstrate altered polarity, which can significantly affect how they grow, migrate, and communicate with their environment. The insights gained from these functional studies have powerful implications in understanding disease mechanisms and developing potential therapeutic interventions.

In research and clinical settings, PARD6A Gene Knockout Cell Lines are indispensable tools for dissecting complex signaling pathways and are valuable in drug discovery efforts aimed at modulating cellular behaviors associated with aberrant PARD6A activity. Compared to traditional methods of gene manipulation, these knockout lines provide a more stable and consistent platform for achieving reproducible results, reducing variability in experimental outcomes.

The distinct advantage of our PARD6A Gene Knockout Cell Lines lies in their specificity and the comprehensive characterizations provided, ensuring researchers can derive meaningful conclusions regarding PARD6A's role in various cellular processes. Our product is designed to meet the rigorous standards of contemporary biological research, signaling a commitment to advancing the understanding of cellular mechanisms.

With extensive expertise in gene editing technologies and a robust pipeline of innovative biological products, our company stands at the forefront of providing quality research tools that empower scientists and clinicians alike. By choosing our PARD6A Gene Knockout Cell Lines, you are investing in a reliable resource that supports crucial breakthroughs in cellular biology and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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