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PALM2AKAP2 Knockout Cell Lines

Gene: PALM2AKAP2

Official Full Name: PALM2 and AKAP2 fusionprovided by HGNC

Gene Summary: This gene belongs to the paralemmin downstream gene (PDG) family defined in PMID:22855693. Paralemmin downstream genes may have evolved contiguously with the paralemmin genes and are associated with other paralemmin paralogs in humans and several other taxa. The gene encodes three distinct protein isoforms, the PALM2 isoform, the AKAP2 isoform and the PALM2-AKAP2 isoform. The biological significance of the PALM2-AKAP2 isoforms is yet unknown. Earlier, PALM2 and AKAP2 were annotated as separate genes and PALM2-AKAP2 was annotated as a readthrough gene. [provided by RefSeq, May 2019]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15383 PALM2AKAP2 Knockout cell line (HeLa) Human PALM2AKAP2 1:3~1:6 Negative Online Inquiry
KO15384 PALM2AKAP2 Knockout cell line (HCT 116) Human PALM2AKAP2 1:2~1:4 Negative Online Inquiry
KO15385 PALM2AKAP2 Knockout cell line (HEK293) Human PALM2AKAP2 1:3~1:6 Negative Online Inquiry
KO15386 PALM2AKAP2 Knockout cell line (A549) Human PALM2AKAP2 1:3~1:4 Negative Online Inquiry

Background

PALM2AKAP2 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the physiological and pathological roles of the PALM2AKAP2 gene, which encodes a protein known for its involvement in organizing signaling complexes within cells. By utilizing CRISPR/Cas9 technology, these cell lines are generated to completely disrupt the expression of the PALM2AKAP2 gene, enabling researchers to assess the impacts of its absence on various cellular functions and signal transduction pathways.

The key functions and mechanisms of these knockout cell lines allow for the investigation of the gene’s role in cellular processes such as cardiac development, neuronal signaling, and cellular response to stimuli. With the gene silenced, researchers can conduct experiments to elucidate its function in health and disease, making these cell lines pivotal tools in molecular biology and translational research.

The scientific importance of PALM2AKAP2 Gene Knockout Cell Lines extends to applications in both research and clinical settings. They can be used to explore pathways involved in cardiomyopathies, neurodegenerative diseases, and various cancers, which may open avenues for targeted therapies and personalized medicine strategies. Their ability to model specific gene loss in a controllable environment makes them indispensable in validating hypotheses regarding gene function.

Compared to alternative models that may rely on pharmacological inhibition or overexpression techniques, which can have off-target effects, these knockout cell lines provide a precise and reliable means to study gene function devoid of such complications. Additionally, they offer consistent genetic backgrounds and are readily adaptable to high-throughput screening applications, enhancing their utility in drug discovery and development.

For researchers and clinicians focused on exploring genetic contributions to disease, these knockout cell lines represent a valuable solution that can drive discovery and foster innovation in biological research. Our company specializes in producing high-quality, custom cell lines to meet diverse research needs, reflecting our commitment to advancing scientific inquiry through precision and reliability in biological products.

Please note that all services are for research use only. Not intended for any clinical use.

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