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PAIP2B Knockout Cell Lines

Gene: PAIP2B

Official Full Name: poly(A) binding protein interacting protein 2Bprovided by HGNC

Gene Summary: Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21402 PAIP2B Knockout cell line (HCT 116) Human PAIP2B 1:2~1:4 Negative Online Inquiry
KO21403 PAIP2B Knockout cell line (HEK293) Human PAIP2B 1:3~1:6 Negative Online Inquiry

Background

PAIP2B Gene Knockout Cell Lines are engineered cellular models designed to specifically disrupt the function of the PAIP2B gene, which is implicated in various cellular processes, including gene expression regulation and protein synthesis modulation. By utilizing CRISPR-Cas9 technology or similar genome-editing methods, these knockout cell lines enable researchers to study the phenotypic changes and molecular pathways that are affected by the loss of PAIP2B function.

The primary mechanism through which PAIP2B Gene Knockout Cell Lines operate involves the targeted deletion of the PAIP2B gene sequences, leading to the abrogation of its protein product. This disruption allows scientists to elucidate the role of PAIP2B in cellular contexts, such as its involvement in the regulation of translation and mRNA stability. As a result, researchers can uncover new insights into cancer biology, neurodegenerative diseases, and other conditions where the regulation of gene expression is perturbed.

In terms of scientific importance, these knockout cell lines serve as invaluable tools for both fundamental research and translational applications. They can be employed in gene function studies, drug target validation, and biomarker discovery, providing crucial data that could drive forward the development of new therapeutic strategies. The ability to model diseases with high specificity allows for more accurate interpretations of experimental results, thus enhancing the validity of findings.

Compared to alternative products, PAIP2B Gene Knockout Cell Lines stand out due to their robustness and reproducibility in various experimental settings. Unlike non-specific inhibitors or siRNA approaches, these knockout lines offer a permanent genetic alteration, ensuring that the results reflect long-term effects rather than transient responses. Additionally, their customizability allows researchers to create models tailored to specific experimental needs, enhancing their utility in diverse applications.

For researchers and clinicians, the value of PAIP2B Gene Knockout Cell Lines lies not only in their ability to unravel the complexities of gene regulation but also in their potential to accelerate scientific discovery and innovation. By providing a reliable framework for the study of gene function and its implications in disease, these cell lines can significantly contribute to the advancement of biomedical research.

Our company is at the forefront of developing high-quality biological products, ensuring that researchers have access to the best tools available to drive their scientific endeavors forward. Our commitment to excellence and innovation enables us to offer products that meet the rigorous standards of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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