Gene: P3H2
Official Full Name: prolyl 3-hydroxylase 2provided by HGNC
Gene Summary: This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15408 | P3H2 Knockout cell line (HeLa) | Human | P3H2 | 1:3~1:6 | Negative | Online Inquiry |
KO15409 | P3H2 Knockout cell line (HCT 116) | Human | P3H2 | 1:2~1:4 | Negative | Online Inquiry |
KO15410 | P3H2 Knockout cell line (HEK293) | Human | P3H2 | 1:3~1:6 | Negative | Online Inquiry |
KO15411 | P3H2 Knockout cell line (A549) | Human | P3H2 | 1:3~1:4 | Negative | Online Inquiry |
P3H2 Gene Knockout Cell Lines represent a cutting-edge biological tool engineered to facilitate the exploration of the functional role of the P3H2 gene in various biological processes. These cell lines are generated through precise gene editing techniques, such as CRISPR-Cas9, enabling researchers to create specific knockout mutations that allow for in-depth analysis of gene function and interaction within cellular pathways.
The key functions of P3H2 gene knockout cell lines include the ability to monitor phenotypic changes post-knockout, analyze pathways affected by the P3H2 gene, and identify potential compensatory mechanisms activated in response to gene disruption. By utilizing these cell lines, researchers can elucidate the role of P3H2 in processes such as collagen biosynthesis, cellular stress responses, and extracellular matrix regulation, all of which are critical for understanding various pathological conditions, including fibrotic diseases and cancer.
In terms of scientific significance, P3H2 gene knockout cell lines have invaluable applications in both research and clinical settings. They can be employed in drug discovery processes, where understanding the implication of P3H2 in disease models may lead to the identification of novel therapeutic targets. Additionally, these cell lines can enhance the understanding of gene-environment interactions and their contributions to disease phenotypes.
Compared to traditional cell lines, P3H2 gene knockout cell lines are superior due to their specificity and reproducibility in studying the P3H2 gene. By offering researchers a targeted approach, they reduce the complexity often associated with off-target effects and background noise prevalent in conventional cell models.
The value of these cell lines to researchers and clinicians lies not only in their ability to produce definitive results concerning gene functionality but also in their potential to bridge the gap between basic research and clinical application. They serve as a vital resource for innovative research efforts aimed at advancing therapeutic strategies and improving patient outcomes.
Our company boasts extensive expertise in genetic engineering and cell line development, ensuring that our P3H2 gene knockout cell lines are produced under stringent quality control standards. By integrating advanced technology with a deep understanding of molecular biology, we deliver products that empower the scientific community to make meaningful discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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