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P3H1 Knockout Cell Lines

Gene: P3H1

Official Full Name: prolyl 3-hydroxylase 1provided by HGNC

Gene Summary: This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20367 P3H1 Knockout cell line (HeLa) Human P3H1 1:3~1:6 Negative Online Inquiry
KO20368 P3H1 Knockout cell line (HCT 116) Human P3H1 1:2~1:4 Negative Online Inquiry
KO20369 P3H1 Knockout cell line (HEK293) Human P3H1 1:3~1:6 Negative Online Inquiry
KO20370 P3H1 Knockout cell line (A549) Human P3H1 1:3~1:4 Negative Online Inquiry

Background

P3H1 Gene Knockout Cell Lines are specialized cellular models in which the P3H1 gene has been systematically disrupted, allowing researchers to investigate the gene's specific functions and its role in various biological processes. By utilizing CRISPR-Cas9 technology or similar genome-editing methods, these cell lines enable the precise knockout of the P3H1 gene, leading to a lack of expression of the P3H1 protein. This disruption facilitates a range of experiments focused on understanding how the absence of P3H1 influences cellular behaviors, signaling pathways, and interactions with other biomolecules.

Key functions of the P3H1 protein are still being elucidated, but it is believed to play critical roles in cellular processes such as collagen maturation and cellular stress responses. Researchers can leverage the unique mechanisms of these knockout cell lines to examine alterations in cell proliferation, differentiation, and apoptosis, contributing valuable insights into developmental biology, tissue engineering, and disease states like fibrosis and cancer.

The scientific importance of P3H1 Gene Knockout Cell Lines extends into both basic and applied research settings. Clinically, they provide a tool for modeling diseases associated with abnormal collagen metabolism, enabling the exploration of potential therapeutic interventions. In contrast to other knockout models, the P3H1 cell lines offer specificity and a reproducible platform for high-throughput screening assays.

One particular advantage of our P3H1 Gene Knockout Cell Lines is their ability to mimic physiological conditions due to their derivation from established human or mammalian cell lines, allowing for more relevant experimental outcomes compared to traditional models. Additionally, our commitment to quality ensures that these cell lines are rigorously validated for performance and consistency.

This product is invaluable for researchers seeking to uncover the complexities of P3H1's biological functions or for clinicians developing targeted therapies. With extensive expertise in producing high-quality biological products, our company stands at the forefront of advancing scientific inquiry, offering researchers essential tools that enhance their capabilities in dissecting gene function and pathology.

Please note that all services are for research use only. Not intended for any clinical use.

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