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OXTR Knockout Cell Lines

Gene: OXTR

Official Full Name: oxytocin receptorprovided by HGNC

Gene Summary: The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08070 OXTR Knockout cell line (HeLa) Human OXTR 1:3~1:6 Negative Online Inquiry
KO08071 OXTR Knockout cell line (HCT 116) Human OXTR 1:2~1:4 Negative Online Inquiry
KO08072 OXTR Knockout cell line (HEK293) Human OXTR 1:3~1:6 Negative Online Inquiry
KO08073 OXTR Knockout cell line (A549) Human OXTR 1:3~1:4 Negative Online Inquiry

Background

OXTR Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the oxytocin receptor (OXTR), a critical component in modulating social behavior, stress response, and reproductive functions. By employing CRISPR-Cas9 technology, these cell lines undergo targeted genomic modifications, leading to the complete knockout of the OXTR gene, which enables researchers to dissect the physiological and pathological roles of oxytocin signaling.

The primary function of OXTR Gene Knockout Cell Lines lies in their ability to provide insights into the consequences of oxytocin receptor absence on cellular signaling pathways. This product allows for the evaluation of changes in gene expression, cell proliferation, and receptor-mediated responses under controlled experimental conditions. By utilizing these cell lines, researchers can investigate novel therapeutic approaches for conditions such as autism spectrum disorders, anxiety disorders, and cardiovascular diseases, where oxytocin signaling is believed to play a pivotal role.

The scientific importance of OXTR Gene Knockout Cell Lines extends into both basic and applied research domains, enabling the identification of new biomarkers and therapeutic targets. Unlike traditional methods that often rely on pharmacological inhibitors or agonists, these knockout models offer a more robust and precise approach to elucidate biological mechanisms without confounding effects of drug specificity.

The unique advantages of OXTR Gene Knockout Cell Lines include their unparalleled specificity, versatility, and reproducibility. Researchers may benefit from the optimized protocol for generating stable cell lines, significantly reducing time and resource investments compared to other knockout strategies and ensuring a high degree of fidelity in experimental outcomes.

For scientists, clinicians, and pharmaceutical developers, this product is invaluable, providing a cutting-edge tool to establish new models for understanding the complexities of oxytocin's role in human health and disease. The development of these cell lines underscores our company’s commitment to advancing innovative research tools, backed by years of expertise in genetic engineering and cell biology, ensuring that users receive high-quality products that drive meaningful scientific discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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