Gene: OTUD7B
Official Full Name: OTU deubiquitinase 7Bprovided by HGNC
Gene Summary: Enables K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Involved in several processes, including negative regulation of protein localization to nucleus; protein deubiquitination; and regulation of intracellular signal transduction. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02110 | OTUD7B Knockout cell line (HeLa) | Human | OTUD7B | 1:3~1:6 | Negative | Online Inquiry |
KO02111 | OTUD7B Knockout cell line (HCT 116) | Human | OTUD7B | 1:2~1:4 | Negative | Online Inquiry |
KO02112 | OTUD7B Knockout cell line (HEK293) | Human | OTUD7B | 1:3~1:6 | Negative | Online Inquiry |
KO02113 | OTUD7B Knockout cell line (A549) | Human | OTUD7B | 1:3~1:4 | Negative | Online Inquiry |
OTUD7B Gene Knockout Cell Lines are genetically modified cellular models designed to provide researchers and clinicians with a powerful tool for studying the functional role of the OTUD7B gene in various biological processes and disease mechanisms. These cell lines are created through advanced CRISPR-Cas9 genome-editing technology, resulting in targeted disruptions of the OTUD7B gene that allow for the systematic analysis of its functions.
The primary mechanism through which OTUD7B gene knockout cell lines operate is by facilitating a loss-of-function approach. By selectively knocking out the OTUD7B gene, researchers can investigate its involvement in pathways related to protein stability, cellular signaling, and immune response. This elucidation contributes to a greater understanding of pathological conditions, including cancer, autoimmunity, and neurodegenerative diseases, where OTUD7B is implicated.
The scientific importance of these knockout cell lines is underscored by their applications in both fundamental and translational research. They serve as invaluable models for drug discovery, therapeutic target validation, and elucidation of disease mechanisms, thereby bridging the gap between basic research and clinical application. Additionally, they can be utilized for high-throughput screening of potential small-molecule inhibitors or gene therapy approaches aimed at restoring normal cellular function.
A significant advantage of OTUD7B gene knockout cell lines over alternative models, such as transient overexpression or RNA interference methods, is their ability to persistently disrupt the gene in a stable manner. This leads to consistent phenotypic outcomes, reduced variability, and more reliable experimental data, making them ideal for long-term studies.
For researchers and clinicians aiming to delve deep into the intricacies of gene function, OTUD7B gene knockout cell lines present an unparalleled resource. They empower users to investigate and manipulate biological pathways with precision, ultimately fostering advancements in therapeutic strategies.
Our company specializes in providing high-quality, precisely engineered biological products that support cutting-edge research. With our extensive expertise, we ensure that our OTUD7B gene knockout cell lines meet the highest standards of reliability and performance, making them an essential addition to your research toolkit.
Please note that all services are for research use only. Not intended for any clinical use.
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